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  • 19-September-2019

    English

    Draft Guidance and Review Documents/Monographs

    The OECD Guidelines for the Testing of Chemicals are a unique tool for assessing the potential effects of chemicals on human health and the environment. They are regularly updated with the assistance of thousands of national experts from OECD member countries. The current deadline for comments is set on 19 September 2019 for the Draft Guidance Document dissolution rate and dispersion stability of nanomaterials.

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  • 19-August-2019

    English

    Adverse Outcome Pathways, Molecular Screening and Toxicogenomics

    Latest releases: The 1st report describes the linkage between inhibition of complex I of the mitochondrial respiratory chain and motor deficit as in parkinsonian disorders. The 2nd report links chronic binding of antagonist to N-methyl-D-aspartate receptors during brain development leading to neurodegeneration. The 3rd report details the linkage between binding and activation of androgen receptor leading to reproductive dysfunction.

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  • 31-July-2019

    English

    OECD Test Guidelines Programme

    The OECD Guidelines for the testing of chemicals are a collection of the most relevant internationally agreed testing methods used by governments, industry and independent laboratories to assess the safety of chemical products. The current work plan is now available.

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  • 24-July-2019

    English

    OECD Series on Principles of Good Laboratory Practice (GLP) and Compliance Monitoring

    The purpose of this document is to give guidance to Receiving Authorities on the evaluation of the GLP compliance status of nonclinical safety studies submitted for regulatory purposes. This guidance does not address the scientific evaluation and interpretation of the submitted data or the risk assessment based on these data.

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  • 24-July-2019

    English

    Series on Testing and Assessment: publications by number

    Children are more vulnerable than adults to environmental hazards, such as those presented by chemicals, due to their physiological differences and unique behaviours. The OECD is working to bring together knowledge and experiences to reduce risks to children’s health from chemicals. This report reviews and updates available information with a focus on direct object mouthing to ensure that potential risks for children are addressed.

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  • 19-July-2019

    English

    Section 4: Health Effects

    Consult the January and February 2019 deadlines for comment of various OECD Guidelines for the Testing of Chemicals: in Vitro 3T3 NRU phototoxicity test; Vitrigel Eye Irritancy Test Method; in vitro Macromolecular Test Method for Eye Hazard Potential; and In Chemico Skin Sensitisation Assays addressing the AOP Key Event of covalent binding to proteins.

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  • 17-July-2019

    English, PDF, 5,364kb

    OECD work on Chemical Safety and Biosafety brochure 2019-2020

    This new edition of the OECD work on Chemical Safety and Biosafety highlights the activities, results and ongoing projects as outlined by the 2019-2020 work programme.

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  • 17-June-2019

    English

    OECD Test Guidelines for the Chemicals

    The OECD Guidelines are a unique tool for assessing the potential effects of chemicals on human health and the environment. Accepted internationally as standard methods for safety testing, the Guidelines are used by professionals in industry, academia and government involved in the testing and assessment of chemicals. These Guidelines are regularly updated with the assistance of thousands of national experts from OECD member countries.

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  • 17-June-2019

    English

    Draft documents for public comments

    This page contains a list of the Guidelines for the Testing of Chemicals.

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  • 9-April-2019

    English

    Webinar Series on Emerging Science to Improve Chemical Safety

    On 11 February 2019, the OECD organised a webinar to learn and discuss new methodologies on liver models for induction, clearance and toxicity. The speakers presented the benefits compared to existing methods in place, the types of chemicals tested, the results obtained, the transferability and economic aspects for routine testing, and any known limitation to the technologies and their applications.

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