Testing of chemicals

New and updated OECD Test Guidelines included in the rolling work-plan with 3R relevance

 

Considerably more harmonised validation and regulatory acceptance procedure has been achieved at the OECD and a number of new Test Guideline proposals with animal welfare aspects are under development.

 

 

TG Title Project 3R relevance
236 Fish Embryo Toxicity Test New Test Guideline Embryo test introducing reduction and refinement compared with the existing Acute Fish Test TG 203. Under validation.
443 Extended One-Generation
Reproduction Toxicity Study
New Test
Guideline
Animal test. An extended one-generation test as a possible reduction alternative to TG 416 (2 generation test) is under development.
  In vitro SHE Cell Transformation Test Draft Guidance document A  possible  reduction  method  if  used  in  a  testing strategy.
  In vitro BALB/C3T3 Cell Transformation Test Draft Guidance document A  possible  reduction  method  if  used  in  a  testing strategy.
487 In Vitro Mammalian Cell Micronucleus Test New Test
Guideline
Provisionally adopted by WNT 20 in April 2008. In vitro  test  (part  of  a  test  battery, it  does  not  fully replace the in vivo TG 474 test), awaits outcome of additional testing.
455 TG for a Stably Transfected Transcriptional Activation Assay for the Detection of Estrogen Receptor Agonists and Antagonists (LUMI-CELL® ER assay) New Test
Guideline
In vitro test that could possibly introduce reduction in animal usage if used in a testing strategy for detection of endocrine disrupting chemicals.
  TG for human recombinant estrogen receptor alpha binding assays (hrERa, 2 protocols) Draft new Test
Guideline
In vitro test that could possibly introduce reduction in animal usage if used in a testing strategy for detection of endocrine disrupting chemicals.
456 TG for the H295R Cell-Based Steroidogenesis Assay New Test
Guideline
In vitro test that could possibly introduce reduction in animal usage if used in a testing strategy for detection of endocrine disrupting chemicals.
4xx TG for a Stably Transfected Transcriptional Activation (STTA) Assay for the Detection of Androgenic and Anti- Androgenic Activity of Chemicals Draft new Test
Guideline
In vitro test that could possibly introduce reduction in animal usage if used in a testing strategy for detection of endocrine disrupting chemicals.
       
439 In Vitro Skin Irritation Test Guideline with a Reconstructed Human Epidermis Model New Test
Guideline
Used as an in vitro test in the sequential testing strategy of  GD 203, under development.
431 In Vitro Skin Corrosion Test Guideline with a Reconstructed Human Epidermis Model New Test Guideline Used as an in vitro test in the sequential testing strategy of  GD 203, under development.
489 Test Guideline for the Comet in vitro Assay in Genotoxicity Testing New Test
Guideline
In vitro test for unscheduled DNA synthesis assay (to be a part of a test strategy).
429 Skin Sensitisation: Local Lymph Node Assay Updated Test Guideline (Original adoption: 24 April 2002) Revised TG429 introduced reduction of animal usage.
xx Using Cytotoxicity Tests to estimate Starting Doses for Acute Oral Systemic Toxicity Tests Draft new Guidance Document Guidance Document under development possibly introducing  reduction  of   animal   usage   in   acute toxicity testing.

 

 

 

Countries list

  • Afghanistan
  • Albania
  • Algeria
  • Andorra
  • Angola
  • Anguilla
  • Antigua and Barbuda
  • Argentina
  • Armenia
  • Aruba
  • Australia
  • Austria
  • Azerbaijan
  • Bahamas
  • Bahrain
  • Bangladesh
  • Barbados
  • Belarus
  • Belgium
  • Belize
  • Benin
  • Bermuda
  • Bhutan
  • Bolivia
  • Bosnia and Herzegovina
  • Botswana
  • Brazil
  • Brunei Darussalam
  • Bulgaria
  • Burkina Faso
  • Burundi
  • Cambodia
  • Cameroon
  • Canada
  • Cape Verde
  • Cayman Islands
  • Central African Republic
  • Chad
  • Chile
  • China (People’s Republic of)
  • Chinese Taipei
  • Colombia
  • Comoros
  • Congo
  • Cook Islands
  • Costa Rica
  • Croatia
  • Cuba
  • Cyprus
  • Czech Republic
  • Côte d'Ivoire
  • Democratic People's Republic of Korea
  • Democratic Republic of the Congo
  • Denmark
  • Djibouti
  • Dominica
  • Dominican Republic
  • Ecuador
  • Egypt
  • El Salvador
  • Equatorial Guinea
  • Eritrea
  • Estonia
  • Ethiopia
  • European Union
  • Faeroe Islands
  • Fiji
  • Finland
  • Former Yugoslav Republic of Macedonia (FYROM)
  • France
  • French Guiana
  • Gabon
  • Gambia
  • Georgia
  • Germany
  • Ghana
  • Gibraltar
  • Greece
  • Greenland
  • Grenada
  • Guatemala
  • Guernsey
  • Guinea
  • Guinea-Bissau
  • Guyana
  • Haiti
  • Honduras
  • Hong Kong, China
  • Hungary
  • Iceland
  • India
  • Indonesia
  • Iraq
  • Ireland
  • Islamic Republic of Iran
  • Isle of Man
  • Israel
  • Italy
  • Jamaica
  • Japan
  • Jersey
  • Jordan
  • Kazakhstan
  • Kenya
  • Kiribati
  • Korea
  • Kuwait
  • Kyrgyzstan
  • Lao People's Democratic Republic
  • Latvia
  • Lebanon
  • Lesotho
  • Liberia
  • Libya
  • Liechtenstein
  • Lithuania
  • Luxembourg
  • Macao (China)
  • Madagascar
  • Malawi
  • Malaysia
  • Maldives
  • Mali
  • Malta
  • Marshall Islands
  • Mauritania
  • Mauritius
  • Mayotte
  • Mexico
  • Micronesia (Federated States of)
  • Moldova
  • Monaco
  • Mongolia
  • Montenegro
  • Montserrat
  • Morocco
  • Mozambique
  • Myanmar
  • Namibia
  • Nauru
  • Nepal
  • Netherlands
  • Netherlands Antilles
  • New Zealand
  • Nicaragua
  • Niger
  • Nigeria
  • Niue
  • Norway
  • Oman
  • Pakistan
  • Palau
  • Palestinian Administered Areas
  • Panama
  • Papua New Guinea
  • Paraguay
  • Peru
  • Philippines
  • Poland
  • Portugal
  • Puerto Rico
  • Qatar
  • Romania
  • Russian Federation
  • Rwanda
  • Saint Helena
  • Saint Kitts and Nevis
  • Saint Lucia
  • Saint Vincent and the Grenadines
  • Samoa
  • San Marino
  • Sao Tome and Principe
  • Saudi Arabia
  • Senegal
  • Serbia
  • Serbia and Montenegro (pre-June 2006)
  • Seychelles
  • Sierra Leone
  • Singapore
  • Slovak Republic
  • Slovenia
  • Solomon Islands
  • Somalia
  • South Africa
  • South Sudan
  • Spain
  • Sri Lanka
  • Sudan
  • Suriname
  • Swaziland
  • Sweden
  • Switzerland
  • Syrian Arab Republic
  • Tajikistan
  • Tanzania
  • Thailand
  • Timor-Leste
  • Togo
  • Tokelau
  • Tonga
  • Trinidad and Tobago
  • Tunisia
  • Turkey
  • Turkmenistan
  • Turks and Caicos Islands
  • Tuvalu
  • Uganda
  • Ukraine
  • United Arab Emirates
  • United Kingdom
  • United States
  • United States Virgin Islands
  • Uruguay
  • Uzbekistan
  • Vanuatu
  • Venezuela
  • Vietnam
  • Virgin Islands (UK)
  • Wallis and Futuna Islands
  • Western Sahara
  • Yemen
  • Zambia
  • Zimbabwe
  • Topics list