Testing of chemicals

Skin

 

Skin Absorbption

TG 427: Skin absorption: in vivo method (2004)
TG 428: Skin absorption: in vitro method (2004)

    
General documents:

No 28: Guidance document for the conduct of skin absorption studies
No 156: Guidance notes on dermal absorption


Skin Corrosion

TG 404: Acute dermal irritation/corrosion (2002)
TG 430: In vitro skin corrosion: transcutaneous electrical resistance test (TER) (2013)


TG 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method (2014)
•    No 190: Summary document on the statistical performace of methods in OECD test guideline 431 for
       Sub-Categorisation


TG 435: In vitro membrane barrier test method for skin corrosion (2006)


No 203
: Guidance document on an integrated approach on testing and assessment (IATA) for skin corrosion and irritation


Skin Irritation

TG 404: Acute dermal irritation/corrosion (2002)


TG 439: In vitro skin irritation: reconstructed human epidermis test method (2013)
•    No 137: Explanatory background document to the OECD test guideline on in vitro skin irritation testing
•    No 159: Validation report for the skin irritation test method using LabCyte Epi-Model24
•    No 155: Peer review report of the validation of the skin irritation test using LabCyte Epi-Model 24


No 203
: Guidance document on an integrated approach on testing and assessment (IATA) for skin corrosion and irritation


Skin Sensitisation

TG 406: Skin sensitisation (1992)
TG 429: Skin sensitisation: Local Lymph Node Assay (2010)
TG 442A: Skin sensitisation: Local Lymph Node Assay: DA (2010)
TG 442B: Skin sensitisation: Local Lymph Node Assay: BrdU-ELISA (2010)


No 168: The adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins: Part 1, Part 2


Projects Under Development:

  • KeratinoSens: An in vitro method for identifying the skin sensitisation potential of chemicals
  • Direct Peptide Reactivity Assay (DPRA): An in chemico method for identifying the skin sensitisation potential of chemicals
  • Human Cell Line Activation Test (h-CLAT): An in vitro method for identifying the skin sensitisation potential of chemicals

 

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