Testing of chemicals


  • Guidance Document on Good In Vitro Method Practices (GIVIMP)

    This document provides detailed guidance on good scientific, technical and quality practices to assure the reliability of data derived from cell and tissue based in vitro toxicity test methods. It primarily targets practitioners working in the development and application of in vitro methods and associated Test Guidelines intended for the regulatory safety assessment of chemicals used in different sectors. The project to develop the guidance has been led by the European Commission’s Joint Research Centre (JRC).

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  • Revised Guidance Document 150 for Evaluating Chemicals for Endocrine Disruption

    The Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals. The document is intended to provide guidance for evaluating chemical using standardised test guidelines.

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  • Adverse Outcome Pathways, Molecular Screening and Toxicogenomics

    OECD assists internationally collaborative efforts on the development of Adverse Outcome Pathways with the aim of defining opportunities for their application in a regulatory context.

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OECD assists countries in harmonising test methods for chemical safety and good laboratory practice, in order to ensure high quality and reliable data and for countries and industry to fully benefit from the OECD agreement on Mutual Acceptance of Data and avoid duplicative testing.


Test Guidelines Programme

The OECD Guidelines for the testing of chemicals are a collection of the most relevant internationally agreed testing methods used by governments, industry and independent laboratories to assess the safety of chemicals. They are primarily used in regulatory safety testing and subsequent chemical notification and registration.


Good Laboratory Practice

The OECD Principles of GLP have been developed to promote the quality, validity and reliability of non-clinical test data used for determining the safety of chemicals and chemical products. OECD works to promote a common understanding of, and harmonised approaches to, matters related to GLP and monitoring of compliance with the GLP Principles.


Endocrine Disrupters

‌‌Endocrine disruptors are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife. Work on this has been given high priority for regulatory authorities in most OECD countries and it has been proposed by UNEP as a SAICM policy emerging issue. 


Animal welfare 

‌‌‌‌‌Over 25 years ago, the OECD recognised the need to protect animals in general and in particular those used in experimental work for chemical safety testing. The progress in OECD on the harmonisation of chemicals testing, in particular the agreement on Mutual Acceptance of Data (MAD), by reducing duplicative testing, will do much to reduce the number of animals used in testing.



Cutting Costs in Chemicals ‌Mgt

Cutting Costs in Chemicals Management Publication. Link to detailed page, which contains a PDF link to the publication. As government regulators are facing tighter budgets and chemical companies need to cut costs, this report describes how, by working together through the OECD, governments and industry save about EUR 150 million each year, while still ensuring that chemical products are properly assessed and managed.‌