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Agricultural pesticides and biocides

OECD Conference on RNAi based Pesticides

 

OECD Conference on RNA interference (RNAi) based pesticides

10-12 April 2019 OECD, Paris


The OECD Conference on RNAi based pesticides provided an overview on the current status and future possibilities for the regulation of externally applied dsRNA-based products that are proposed for use as pesticides. The event facilitated exchanges between policy makers, academia, industry on their implications in health, environment, and regulation. 

The focus on regulatory needs and aspects of risk assessment also aimed at informing the use of public and government funds in support of research on the use of externally applied dsRNA in agricultural agencies and institutes. 

Finally, hearing from regulatory authorities that have reviewed dsRNA-based crop traits helped informing regulatory policies at the national and international level and facilitate the development of a harmonised approach for regulating externally applied dsRNA-based plant protection products.

The Conference not only provided an overview but also inputs and recommendations for guidance(s) to be developed by the Working Group on Pesticides (WGP) and especially by its Expert Group working on RNAi-based pesticides. The guidance document(s) developed was made publicly available as practical tool(s) for policy makers and regulators of pesticides all over the world. 

 

Programme

DAY 1 - 10 April 2019


Openin
g: 

Welcome by the OECD: Richard Sigman - OECD Environment Directorate

Welcome by the CRP and introduction to the Programme

SESSION 1: Summary of the State of the Art: dsRNA based Product Use in Agriculture

Objective This session provided a background on the molecular mechanism of RNAi and relevant related pathways, reviewed the current understanding of cross-kingdom RNAi, examined the species-specificity of these dsRNAs on non-target species and discussed challenges related to the RNAi-efficiency in insects. 
Speakers
 

The following series of presentations will further discuss the research to date investigating the factors that affect insects’ responsiveness to environmental dsRNA, cover approaches to assess biodegradation of dsRNA in different matrices and explore the role of RNA-Seq to predict genetic changes and impact the efficacy of RNAi products in target pests. They will also summarise the published literature related to dietary uptake of external dsRNA in humans and address the lessons learnt from human therapeutic use of dsRNA.


DAY 2 - 11 April 2019

SESSION 2: Summary of Regulatory & Risk Assessment Experience with dsRNA-based Products

Objective This session described how problem formulation can guide risk assessments for spray applications of pesticides containing dsRNA, and consider potential pathways and testable risk hypothesis in the context of environmental risk assessment. It also covered the experience gathered from the risk assessment of genetically-modified crop plants, which incorporate the machinery to synthesise RNA molecules specifically directed against a pest species feeding on the crop (so-called ‘plant-incorporated protectants’, or PIPs).
Speakers

 

Conference documents

 

Supported by

The OECD’s Co-operative Research Programme: Biological Resource Management for Sustainable Agricultural Systems

: Summary of the State of the Art: dsRNA-based Product Use in Agriculture

 

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