Latest Documents


  • 9-October-2017

    English

    Test No. 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants

    This Test Guideline describes an in vitro assay that may be used for identifying water soluble ocular corrosives and severe irritants as defined by the UN Globally Harmonized System of Classification and Labelling, Category 1. The assay is performed in a well where a confluent monolayer of Madin-Darby Canine Kidney (MDCK) is used as a separation between two chambers. It uses a fluorescein dye as marqueur. The test substance has the potential to impair the junctions of the MDCK cells and thus to increase the monolayer¡¯s permeability. Consequently the fluorescein passes through the monolayer and the fluorescein leakage (FL) increases. The FL is calculated as a percentage of leakage relative to both a blank control and a maximum leakage control. The concentration of test substance that causes 20% FL (FL20, in mg/mL) is calculated and used in the prediction model for identification of ocular corrosive and severe irritants. The cut-off value of FL20 to identify water soluble chemicals as ocular corrosives/severe irritants is ¡Ü 100mg/mL. The FL test method should be part of a tiered testing strategy.
  • 9-October-2017

    English

    Test No. 247: Bumblebee, Acute Oral Toxicity Test

    This test guideline is a laboratory test method, designed to assess the acute oral toxicity of pesticides and other chemicals to adult worker bumblebees.Adult worker bumblebees are exposed to 50 % (w/v) aqueous sucrose solution containing the test chemical. The test duration is at least 48 h. Mortality is recorded daily and compared with control values. Results are analysed in order to calculate the LD50 and NOED, if possible, at 24 h & 48 h and furthermore at 72 h & 96 h in case the study is prolonged.
  • 9-October-2017

    English

    Test No. 245: Honey Bee (Apis Mellifera L.), Chronic Oral Toxicity Test (10-Day Feeding)

    This Test Guideline describes a chronic oral toxicity test on adult worker honey bees under laboratory conditions over an exposure period of 10 days.Young bees (max. 2 days old) are exposed to 50 % (w/v) aqueous sucrose solution containing the test chemical by continuous and ad libitum feeding over a period of 10 days. Mortality and behavioural abnormalities are observed and recorded daily during the 10 day test period. The chronic effects of the test chemical are evaluated by comparing the results of the test chemical treated group to those of the respective control group. The test is designed for the determination of the following endpoints  LC50 (median Lethal Concentration) and the LDD50 (median Lethal Dietary Dose) values after 10 days of exposure, and NOEC (No Observed Effect Concentration) and NOEDD (No Observed Effect Dietary Dose). 
  • 9-October-2017

    English

    Test No. 246: Bumblebee, Acute Contact Toxicity Test

    This test guideline is a laboratory test method, designed to assess the acute contact toxicity of pesticides and other chemicals to adult worker bumblebees.Adult worker bumblebees are exposed to the test chemical dissolved in an appropriate carrier, by direct application to the dorsal thorax (droplet). The test duration is at least 48 h. Mortality is recorded daily and compared with control values. Results are analysed in order to calculate the LD50 and NOED, if possible, at 24 h & 48 h and furthermore at 72 h & 96 h in case the study is prolonged.
  • 9-August-2017

    English

    Portal on Per and Poly Fluorinated Chemicals

    Per- and poly-fluorinated alkyl substances (PFASs) are substances that have many manufacturing and industrial applications because they impart useful properties (fire resistance and oil, stain, grease and water repellency). Some of the properties are associated with environmental and human health concerns. To support a global transition towards safer alternatives, this Portal facilitates the exchange of information.

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  • 31-July-2017

    English

    Perfluorooctane Sulfonate (PFOS) and related chemical products

    Hazard Assessment of Perfluorooctane Sulfonate (PFOS) and its Salts for human health and the environment, as a result of its investigation in the OECD Existing Chemicals Programme.

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  • 31-July-2017

    English

    Series on Risk Management - Work on Specific Chemical Exposures of Concern

    Publications from the Series on Risk Management which relate to Work on Specific Chemical Exposures of Concern.

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  • 19-June-2017

    English

    Unique Identifier for Transgenic Plants

    The OECD developed the BioTrack Product Database which accommodates Unique Identifiers to each transgenic (or genetically engineered) plant that is approved for commercial use, including planting and food/feed use. These Unique Identifiers are intended to be used as "keys" to access information of each transgenic product in this database and to ensure the safety of modern biotechnology products

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  • 22-May-2017

    English

    Consensus documents: work on harmonisation of regulatory oversight in biotechnology

    These documents focus on the biology of organisms (such as plants, trees or micro-organisms) or introduced novel traits.

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  • 11-May-2017

    English

    Sustainable Chemistry

    The new OECD report on "Economic Features of Chemical Leasing" is a review of the literature on the economic features of the Chemical Leasing, focusing on the drivers and barriers and comparing its functioning to traditional contracts.

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