Latest Documents

  • 18-May-2009

    English, , 123kb

    Need for research and development programmes in sustainable chemistry

    The purpose of this document is to provide guidance to governments which would like to develop their own programmes to promote R&D in sustainable chemistry that take account of national priorities and policies.

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  • 4-May-2009


    Introduction to (Quantitative) Structure Activity Relationships

    Structure-Activity Relationship (SAR) is an approach designed to find relationships between chemical structure (or structural-related properties) and biological activity (or target property) of studied compounds. As such it is the concept of linking chemical structure to a chemical property (e.g., water solubility) or biological activity including toxicity (e.g., fish acute mortality). Qualitative SARs and quantitative SARs,

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  • 17-April-2009

    English, , 282kb

    Preliminary Analysis of Exposure Measurement and Exposure Mitigation in Occupational Settings

    This report provides preliminary analyses and recommendations as well as brief summaries of background documen

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  • 3-April-2009

    English, , 483kb

    Nanosafety Research Database Brochure

    As part of the OECD activities to promote international co-operation in addressing human health and environmental safety aspects of manufactured nanomaterials, the OECD has developed a global resource which details research projects that address safety issues of manufactured nanomaterials. This database holds details of completed, current and planned research projects on safety, which are to be updated and managed electronically by

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  • 30-January-2009

    English, , 858kb

    Data Analysis of the Identification of Correlations between Polymer Characteristics and Potential for Health or Ecotoxicological Concern

    This document contains an analysis of data on 205 polymers to identify correlations between polymer characteristics and the potential for health or ecotoxicological concern.

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  • 5-January-2009

    English, , 872kb

    Interim Report- Nanoscale Materials Stewardship Program

    The Nanoscale Materials Stewardship Program (NMSP) was developed to help provide a firmer scientific foundation for regulatory decisions by encouraging submission and development of information for nanoscale materials. The NMSP comprised two sub-programs, the Basic Program and the In-Depth Program. When the NMSP was initiated, EPA committed to issue this interim report after one year. The Agency welcomes comments on this interim

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  • 22-December-2008

    English, , 471kb

    Working Document on the Evaluation of Microbials for Pest Control

    The Pesticides Programme has undertaken work to: (i) identify and overcome obstacles to work-sharing; (ii) harmonise data requirements and test guidelines; and (iii) harmonise hazard/risk assessment approaches.

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  • 19-November-2008

    English, , 282kb

    Guidance Document on the Evaluation of Efficacy of Antimicrobial Treated Articles with Claims for External Effects

    This guidance document focuses on microbiological efficacy testing. It covers efficacy testing of articles treated with antimicrobials in the manufacturing process with the intention of the achieving an external effect.

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  • 16-October-2008


    Test No. 228: Determination of Developmental Toxicity of a Test Chemical to Dipteran Dung Flies(Scathophaga stercoraria L. (Scathophagidae), Musca autumnalis De Geer (Muscidae))

    This Test Guideline describes a method to estimate the developmental toxicity of a test chemical to the dung dwelling life stages of dung-dependent dipteran species. Two test species can be used. The test chemical is mixed with bovine faeces, to which either 10 eggs of Scathophaga stercoraria or 10 larvae of Musca autumnalis are added. The test will be terminated 5 days after emergence of the last adult in the control (> 18 days for S. stercoraria, >13 days for M. autumnalis). Then the possible impacts of the test chemical on the following measurement endpoints are assessed under controlled conditions: sex and total number of emerged adult flies, retardation of emergence indicated by the developmental rate and morphological change. Depending on the experimental design, the No Observed Effect Concentration (NOEC) or the Effect concentration for x percent effect (ECx) can be determined. This Guideline can be used for water soluble or insoluble substances, but is not applicable to volatile substances. If the toxicity of the chemical is unknown, five nominal test concentrations should be conducted. A positive control should be tested periodically. The test is considered valid if in the controls hatching of larvae is superior or equal to 70% of the number of introduced eggs, emergence of adults is superior or equal to 70% and superior or equal to 50% of the respectively hatched and introduced larvae and if the emergence of adult flies starts after 18 +- 2 days (S. stercoraria) or after 13 +- 2 days(M. autumnalis).
  • 16-October-2008


    Test No. 226: Predatory mite (Hypoaspis (Geolaelaps) aculeifer) reproduction test in soil

    This Test Guideline describes a method to assess the effects of chemical substances in soil on the reproductive output of the soil mite species Hypoaspis (Geolaelaps) aculeifer Canestrini (Acari: Laelapidae). It can be used for water soluble or insoluble substances, but not with volatile substances.Adult females of similar age are exposed to a range of concentrations of the test substance mixed into 20 g dry mass of artificial soil 28-35 days after the start of the egg laying period. Depending on the endpoint (ECx, NOEC or both), five to twelve concentrations should be tested. At least two to four replicates for each test concentrations and six to eight control replicates, of 10 animals each, are recommended. At 20¡ãC, the test lasts 14 days after introducing the females, which usually allows the control offspring to reach the deutonymph stage. The number of surviving females (mortality ¡Ü 20% for a valid test) and the number of juveniles per test vessel (at least 50 for a valid test) are determined. The fecundity of the mites exposed to the test substance is compared to that of controls in order to determine the ECx (e.g. EC10, EC50) or the No Observed Effect Concentration (NOEC). Any observed differences between the behaviour and the morphology of the mites in the control and the treated vessels should be recorded.
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