Structure-Activity Relationship (SAR) is an approach designed to find relationships between chemical structure (or structural-related properties) and biological activity (or target property) of studied compounds. As such it is the concept of linking chemical structure to a chemical property (e.g., water solubility) or biological activity including toxicity (e.g., fish acute mortality). Qualitative SARs and quantitative SARs,
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This report provides preliminary analyses and recommendations as well as brief summaries of background documen
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As part of the OECD activities to promote international co-operation in addressing human health and environmental safety aspects of manufactured nanomaterials, the OECD has developed a global resource which details research projects that address safety issues of manufactured nanomaterials. This database holds details of completed, current and planned research projects on safety, which are to be updated and managed electronically by
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This document contains an analysis of data on 205 polymers to identify correlations between polymer characteristics and the potential for health or ecotoxicological concern.
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The Nanoscale Materials Stewardship Program (NMSP) was developed to help provide a firmer scientific foundation for regulatory decisions by encouraging submission and development of information for nanoscale materials. The NMSP comprised two sub-programs, the Basic Program and the In-Depth Program. When the NMSP was initiated, EPA committed to issue this interim report after one year. The Agency welcomes comments on this interim
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The Pesticides Programme has undertaken work to: (i) identify and overcome obstacles to work-sharing; (ii) harmonise data requirements and test guidelines; and (iii) harmonise hazard/risk assessment approaches.
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This guidance document focuses on microbiological efficacy testing. It covers efficacy testing of articles treated with antimicrobials in the manufacturing process with the intention of the achieving an external effect.
This Test Guideline describes a method to estimate the developmental toxicity of a test chemical to the dung dwelling life stages of dung-dependent dipteran species. Two test species can be used. The test chemical is mixed with bovine faeces, to which either 10 eggs of Scathophaga stercoraria or 10 larvae of Musca autumnalis are added. The test will be terminated 5 days after emergence of the last adult in the control (> 18 days for S. stercoraria, >13 days for M. autumnalis). Then the possible impacts of the test chemical on the following measurement endpoints are assessed under controlled conditions: sex and total number of emerged adult flies, retardation of emergence indicated by the developmental rate and morphological change. Depending on the experimental design, the No Observed Effect Concentration (NOEC) or the Effect concentration for x percent effect (ECx) can be determined. This Guideline can be used for water soluble or insoluble substances, but is not applicable to volatile substances. If the toxicity of the chemical is unknown, five nominal test concentrations should be conducted. A positive control should be tested periodically. The test is considered valid if in the controls hatching of larvae is superior or equal to 70% of the number of introduced eggs, emergence of adults is superior or equal to 70% and superior or equal to 50% of the respectively hatched and introduced larvae and if the emergence of adult flies starts after 18 +- 2 days (S. stercoraria) or after 13 +- 2 days(M. autumnalis).
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The report is a collation of various aspects such as responsible regulatory authorities/agencies, data requirements, activities being pursued and regulatory mechanisms for approving minor uses in member countries.
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This report presents the results of an OECD seminar on ways to achieve risk reduction while addressing issues associated with the use of chemical pesticides or non-chemical means of crop protection on a small scale.