Latest Documents


  • 8-September-2009

    English

    Test No. 455: The Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals

    This Test Guideline describes an in vitro assay, which  provides mechanistical information, and can be used for screening and prioritization purposes. The test system utilises the hERalpha-HeLa-9903 cell line derived from a human cervical tumor and stably transfected. This cell line can measure the ability of a test chemical to induce hERalpha-mediated transactivation of luciferase gene expression. The cells are exposed to 7 non-cytotoxic concentrations of the test chemical for 20-24 hours to induce the reporter gene products. Four reference chemicals should be included in each experiment: a strong estrogen (17beta-estradiol), a weak estrogen (17alpha-estradiol), a very weak estrogen (17alpha-methyltestosterone) and a negative control (corticosterone). The activity of the luciferase enzyme is measured in a luminometer. A test chemical is considered to be positive if the maximum response induced is equal to or exceeds 10% of the response of the positive control (1 nM 17alpha-estradiol) in at least two of two or two of three runs.

    Software to be used with TG 425, 432, 455. Click here. Software not part of the Mutual Acceptance of Data.

  • 8-September-2009

    English

    Test No. 438: Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants

    The Isolated Chicken Eye  (ICE) test method is an in vitro test method that can be used to classify substances as “ocular corrosives and severe irritants”. The ICE method uses eyes collected from chickens obtained from slaughterhouses where they are killed for human consumption, thus eliminating the need for laboratory animals. The eye is enucleated and mounted in an eye holder with the cornea positioned horizontally. The test substance and negative/positive controls are applied to the cornea. Toxic effects to the cornea are measured by a qualitative assessment of opacity, a qualitative assessment of damage to epithelium based on fluorescein retention, a quantitative measurement of increased thickness (swelling), and a qualitative evaluation of macroscopic morphological damage to the surface. The endpoints are evaluated separately to generate an ICE class for each endpoint, which are then combined to generate an Irritancy Classification for each test substance.

  • 27-August-2009

    English

    Guidance Manual for the Testing of Manufactured Nanomaterials: OECD's Sponsorship Programme: Number 14

    This Guidance Manual for the Testing of Manufactured Nanomaterials, is a “living document” and as such, it will be updated and amended in an iterative manner based upon knowledge accumulation as the testing programme and Dossier Development Plans (DDPs) work progresses.

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  • 15-August-2009

    English

    Series on Testing and Assessment / Adopted Guidance and Review Documents

    These are the OECD Guidelines for the Testing of Chemicals: Testing and Assessment Series Monographs.

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  • 7-August-2009

    English, , 279kb

    Microbials Guidance Main document

    OECD Guidance for Country Data Review Reports on Microbial Pest Control Agents (Monograph Guidance for Microbials), Series on Pesticides No 22 - Main document

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  • 5-August-2009

    English

    Sustainable Chemistry Platform

    Development of this siteThis website has been developed by the Issue Team on Sustainable Chemistry which is part of the OECD Environment, Health and Safety Programme. Germany served as a lead country in the development of this website. Purpose of the Sustainable Chemistry PlatformThis site was set up to facilitate information exchange, review of new developments and further elaboration of incentives for Sustainable Chemistry and to

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  • 4-August-2009

    English, , 281kb

    Dossier Guidance for Microbials

    OECD Guidance for Industry Data Submissions for Microbial Pest Control Products and their Microbial Pest Control Agents (Dossier Guidance for Microbials), Series on Pesticides No. 23 - Main document

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  • 9-July-2009

    English, , 271kb

    EHS Research Strategies on Manufactured Nanomaterials: Compilation of Outputs

    This document comprises the compilation of output documents that have been produced duringthe course of the work of the project, and that can be useful to a wider audience, in addition to the WPMN.

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  • 9-July-2009

    English, , 4,583kb

    Report of an OECD Workshop on Exposure Assessment and Exposure Mitigation:Manufactured Nanomaterials

    This document is the report of the OECD Workshop on Exposure Assessment and Exposure Mitigation, which was held on 20 October 2008, in Frankfurt, Germany. This report includes a summary of the plenary presentations as w

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  • 9-July-2009

    English

    OECD Conference on Potential Environmental Benefits of Nanotechnology: Fostering Safe Innovation-Led Growth

    This conference, which took place in Paris on 15-17 July 2009, will significantly contribute to accelerating OECD’s current efforts for fostering “green” and innovation-led growth in nanotechnology.

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