Latest Documents

21-September-2018

English

Integrated Approaches to Testing and Assessment (IATA)

The four new cases includes aspects regarding use of IATA for prioritisation and consideration of the properties of nanomaterials for read-across as well as learning on the application of read-across for repeated dose toxicity.

12-September-2018

English

Webinar: Best Environmental Practices (BEP) for textiles in the context of management of per- and polyfluoroalkyl Substances (PFASs)

Join us for our per- and polyfluoroalkyl substances webinar on Best Environmental Practices (BEP) for Textiles

4-September-2018

English

Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption

This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals. The document is intended to provide guidance for evaluating chemical using standardised test guidelines.

4-September-2018

English

OECD Work Related to Endocrine Disrupters

The OECD has published the Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.

4-September-2018

English

Guidance Document on Good In Vitro Method Practices (GIVIMP)

GIVIMP aims to reduce the uncertainties in cell and tissue-based in vitro method derived predictions by applying good scientific, technical and quality practices from method development to implementation for regulatory use. Test method developers and test guideline users will find best practices for designing guideline in vitro methods, carrying out safety tests and assuring quality and scientific integrity of the resulting data

31-July-2018

English

Call for data on per- and polyfluoroalkyl substances (PFASs) and alternatives

The OECD is aiming to collect data for a new report on PFASs and Alternatives - Commercial Availability and Current Uses. A questionnaire is available to provide information on current uses of alternatives to PFASs on the following sectors: textile and shoes, firefighting foam and food packaging. Industry, public authorities, NGOs and academia are invited to participate. Please note that the deadline for response is 31 July 2018.

5-July-2018

English

Chemical Safety and Biotechnology News

This Chemical Safety and Biosafety news release provides an update on the recent projects, events and publications.

28-June-2018

English

Genome Editing: Applications in Agriculture

The OECD Conference on Genome Editing: Applications in Agriculture – Implications for Health, Environment and Regulation will explore the regulatory considerations raised by genome edited products, with the aim to favour a coherent policy approach to facilitate innovation involving genome editing. More information on the programme and the speakers.

27-June-2018

English

Test No. 442B: Skin Sensitization - Local Lymph Node Assay: BrdU-ELISA or –FCM

The Local Lymph Node Assay: BrdU-ELISA (LLNA:BrdU-ELISA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The method described in mouse is based on the use of measuring 5-bromo-2-deoxyuridine (BrdU) content, an analogue of thymidine, as an indicator of this proliferation. A minimum of four animals is used per dose group, with a minimum of three concentrations of the test substance, plus a concurrent negative control group and a positive control group. The experimental schedule is during 6 days. Thereafter, the animals are killed and a single cell suspension of lymph node cells (LNC) is prepared. The procedure for preparing the LNC is crucial, in particular for the small lymph nodes in NC animals. Then the BrdU content in DNA of lymphocytes is measured by ELISA using a commercial kit of by Flow Cytometry (FCM). This study includes: measurements (weighing, BrdU) and clinical daily observations. The results are expressed as the Stimulation Index (SI) obtained by calculation from the mean BrdU labelling index. The SI should be ≥1.6 for the ELISA method or ≥2.7 for the FCM method for identifying the test material as a potential skin sensitizer.

27-June-2018

English

Test No. 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage

This Test Guideline describes an in vitro procedure allowing the identification of chemicals (substances and mixtures) not requiring classification and labelling for eye irritation or serious eye damage in accordance with UN GHS. It makes use of reconstructed human cornea-like epithelium (RhCE) which closely mimics the histological, morphological, biochemical and physiological properties of the human corneal epithelium. The test evaluates the ability of a test chemical to induce cytotoxicity in a RhCE tissue construct, as measured by the MTT assay. Coloured chemicals can also be tested by used of an HPLC procedure. RhCE tissue viability following exposure to a test chemical is measured by enzymatic conversion of the vital dye MTT by the viable cells of the tissue into a blue MTT formazan salt that is quantitatively measured after extraction from tissues. The viability of the RhCE tissue is determined in comparison to tissues treated with the negative control substance (% viability), and is then used to predict the eye hazard potential of the test chemical. Chemicals not requiring classification and labelling according to UN GHS are identified as those that do not decrease tissue viability below a defined threshold (i.e., tissue viability > 60%, for UN GHS No Category).

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