Latest Documents


  • 9-October-2017

    English

    Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure

    This method provides information on health hazard likely to arise from short-term exposure to a test chemical by inhalation.

    It is a principle of the method that only moderately toxic concentrations are used so that ‘evident toxicity’, rather than death/moribundity is used as an endpoint, and concentrations that are expected to be lethal are avoided.

    Groups of animals of a single sex are exposed for a short period of time to the test chemical in a stepwise procedure using the appropriate fixed concentrations for vapours, dusts/mists (aerosols) or gases.  Further groups of animals may be tested at higher concentrations in the absence of signs of evident toxicity or mortality at lower concentrations. This procedure continues until the concentration causing evident toxicity or no more than one death/ moribund animal is identified, or when no effects are seen at the highest concentration or when deaths/ moribundity occur at the lowest concentration.  A total of five animals of one sex will normally be used for each concentration level investigated. The results of this study include: measurements (weighing at least weekly) and daily detailed observations, as well as gross necropsy. The method provides information on the hazardous properties and allows the substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals.

     

  • 9-October-2017

    English

    Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

    This Test Guideline describes a cytotoxicity-based in vitro assay that is performed on a confluent monolayer of Statens Seruminstitut Rabbit Cornea (SIRC) cells, cultured on a 96-well polycarbonate microplate. After five-minute exposure to a test chemical, the cytotoxicity is quantitatively measured as the relative viability of SIRC cells using the MTT assay. Decreased cell viability is used to predict potential adverse effects leading to ocular damage. Cell viability is assessed by the quantitative measurement, after extraction from the cells, of blue formazan salt produced by the living cells by enzymatic conversion of the vital dye MTT, also known as Thiazolyl Blue Tetrazolium Bromide. The obtained cell viability is compared to the solvent control (relative viability) and used to estimate the potential eye hazard of the test chemical. A test chemical is classified as UN GHS Category 1 when both the 5% and 0.05% concentrations result in a cell viability smaller than or equal to (≤) 70%. Conversely, a chemical is predicted as UN GHS No Category when both 5% and 0.05% concentrations result in a cell viability higher than (>) 70%.

  • 9-October-2017

    English

    Test No. 246: Bumblebee, Acute Contact Toxicity Test

    This test guideline is a laboratory test method, designed to assess the acute contact toxicity of pesticides and other chemicals to adult worker bumblebees.

    Adult worker bumblebees are exposed to the test chemical dissolved in an appropriate carrier, by direct application to the dorsal thorax (droplet). The test duration is at least 48 h. Mortality is recorded daily and compared with control values. Results are analysed in order to calculate the LD50 and NOED, if possible, at 24 h & 48 h and furthermore at 72 h & 96 h in case the study is prolonged.

  • 26-September-2017

    English

    Series on Testing and Assessment: publications by number

    This guidance provides an overarching framework on how to apply available tools to assess the bioavailability of metals in the context of ecological risk assessment.

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  • 21-September-2017

    English

    The OECD QSAR Toolbox

    Download and install the QSAR toolbox version 4.1 patch. It provides a fix for installation issues and additional bugs.

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  • 8-September-2017

    English

    Participate in the survey: Guiding Principles for Chemical Accident Prevention, Preparedness and Response

    This short survey aims to gather feedback from a wide range of stakeholders on the OECD Guiding Principles for Chemical Accidents Prevention, Preparedness. The feedback received from this survey will help us making sure the new version is an improvement from the past and that it meets current needs of users.

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  • 28-August-2017

    English

    OECD Council Acts Related to Chemicals

    List of the Council Decisions and Council Recommendations, known collectively as Council Acts, that are relevant to the work of the Chemicals Programme.

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  • 9-August-2017

    English

    Portal on Per and Poly Fluorinated Chemicals

    Per- and poly-fluorinated alkyl substances (PFASs) are substances that have many manufacturing and industrial applications because they impart useful properties (fire resistance and oil, stain, grease and water repellency). Some of the properties are associated with environmental and human health concerns. To support a global transition towards safer alternatives, this Portal facilitates the exchange of information.

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  • 1-August-2017

    English

    Intellectual Property elements in OECD Test Guidelines

    OECD Test Guidelines are used by member countries and industry to generate chemical safety data. Therefore, Test Guidelines need to be broadly available, and transparently described while open to innovation.

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  • 31-July-2017

    English

    Perfluorooctane Sulfonate (PFOS) and related chemical products

    Hazard Assessment of Perfluorooctane Sulfonate (PFOS) and its Salts for human health and the environment, as a result of its investigation in the OECD Existing Chemicals Programme.

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