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  • 2-November-2020

    English

    Biological pesticides

    The programme (or BioPesticides including microbials - bacteria, algae, protozoa viruses, fungi -, pheromones and semiochemicals, macrobials/invertebrates such as insects and nematodes, and plant extracts/botanicals) helps member countries to harmonise the methods and approaches used to assess biological pesticides.

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  • 9-October-2020

    English

    Series on Risk Management - Publications by number

    This workshop aimed to foster a discussion on real-world policy misalignment at the chemicals/waste interface in order to identify and review potential, or already applied, solutions. In order to support this discussion, case studies were submitted and addressed different sectors and issues.

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  • 8-October-2020

    English

    Integrated Approaches to Testing and Assessment (IATA)

    The aim of this document is to give an overview of existing guidance on Integrated Approaches to Testing and Assessment (IATA) and their component parts. While the number of documents, from different sources, directly or indirectly related to guidance on IATA, is proliferating, the information is fragmented and hard to find.

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  • 30-September-2020

    English

    Agricultural Pesticides

    This report provides recommendations on risk assessment considerations for exogenously-applied double-stranded RNA (dsRNA)-based products, with a focus on issues relating to data requirements for determining the environmental fate of sprayable RNA molecules and for examining the potential risks to non-target organisms. It provides scientific information and considerations to regulate RNA interference (RNAi) technology for pest control.

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  • 25-September-2020

    English

    Pesticides publications (Chronological order)

    Two new reports have been released in the Series on Pesticides: A Guidance Document for the Assessment of the Equivalence of Technical Grade Active Ingredients for Identical Microbial Strains and a Guidance Document on Residues in Rotational Crops.

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  • 11-September-2020

    English

    Best Available Techniques (BAT) to Prevent and Control Industrial Pollution

    This report aims to provide the governments with relevant steps, tools and best practices on how to identify and establish BAT, BAT-associated emission levels (BAT-AELs) and other environmental performance levels (BAT-AEPLs), as well as BAT-based permit conditions, including emission limit values.

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  • 12-August-2020

    English

    Pesticide risk reduction

    This page tells about the OECD Pesticide Risk Reduction project.

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  • 29-June-2020

    English

    Test No. 405: Acute Eye Irritation/Corrosion

    This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is applied in a single dose in the conjunctival sac of one eye of each animal. The other eye, which remains untreated, serves as a control. The initial test uses an animal; the dose level depends on the test substance nature. A confirmatory test should be made if a corrosive effect is not observed in the initial test, the irritant or negative response should be confirmed using up to two additional animals. It is recommended that it be conducted in a sequential manner in one animal at a time, rather than exposing the two additional animals simultaneously. The duration of the observation period should be sufficient to evaluate fully the magnitude and reversibility of the effects observed. The eyes should be examined at 1, 24, 48, and 72 hours after test substance application. The ocular irritation scores should be evaluated in conjunction with the nature and severity of lesions, and their reversibility or lack of reversibility. Use of topical anesthetics and systemic analgesics to avoid or minimize pain and distress in ocular safety testing procedures is described.

  • 29-June-2020

    English

    Test No. 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals

    This Test Guideline describes in vitro assays, which use Androgen Receptor TransActivation (ARTA) to detect Androgen Receptor Agonists and Antagonists. The ARTA assay methods are mechanistically and functionally similar test methods that provide information on the transcription and translation of a reporter gene following the binding of a chemical to the androgen receptor and subsequent transactivation. The cell lines used in these assays express AR and have been stably transfected with an AR-responsive luciferase reporter gene, and are used to identify chemicals that activate (i.e. act as agonist) or inhibit (i.e. act as antagonists) AR-dependent transcription. Some chemicals may, in a cell type-dependent manner, display both agonist and antagonist activity and are known as selective AR modulators. The AR is activated following ligand binding, after which the receptor-ligand complex binds to specific DNA responsive elements and transactivates the receptor gene, resulting in an increase cellular expression of the luciferase enzyme. The enzyme then transforms the substrate to a bioluminescent product that can be quantitatively measured with a luminometer. This Test Guideline includes ARTA assays using the AR-EcoScreenTM cell line, the AR-CALUX® cell line, and 22Rv1/MMTV_GR-KO cell line.

  • 29-June-2020

    English

    Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

    This Test Guideline describes a cytotoxicity-based in vitro assay that is performed on a confluent monolayer of Statens Seruminstitut Rabbit Cornea (SIRC) cells, cultured on a 96-well polycarbonate microplate. After five-minute exposure to a test chemical, the cytotoxicity is quantitatively measured as the relative viability of SIRC cells using the MTT assay. Decreased cell viability is used to predict potential adverse effects leading to ocular damage. Cell viability is assessed by the quantitative measurement, after extraction from the cells, of blue formazan salt produced by the living cells by enzymatic conversion of the vital dye MTT, also known as Thiazolyl Blue Tetrazolium Bromide. The obtained cell viability is compared to the solvent control (relative viability) and used to estimate the potential eye hazard of the test chemical. A test chemical is classified as UN GHS Category 1 when both the 5% and 0.05% concentrations result in a cell viability smaller than or equal to (≤) 70%. Conversely, a chemical is predicted as UN GHS No Category when both 5% and 0.05% concentrations result in a cell viability higher than (>) 70%.
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