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This report includes the conclusions and recommendations of an expert workshop on the genotoxicity of nanomaterials, which was organized by OECD’s Working Party on Manufactured Nanomaterials. The main topic was the applicability of existing OECD Test Guidelines (TG) for chemical safety to nanomaterials.
OECD countries have developed PRTR system to track releases and transfers of potentially harmful chemicals. To improve PRTR system, OECD have analysed common elements (pollutants, sectors) in different PRTR systems, mainly focus on institutional arrangement. This serves as a common framework for different PRTR system, and supporting materials for a country that intends to develop or update its PRTR.
PRTR have been established throughout the world to track releases and transfers of potentially harmful chemicals. But most of the PRTR systems were designed without considering comparability, each PRTR has its own requirement of reporting chemicals and sectors. To harmonise globally, OECD reviewed the reporting chemicals and sectors across PRTR systems and produced proposal for harmonised lists of reporting pollutants.
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A cooperative global approach to the regulation of agricultural pesticides and sustainable pest management. Pesticides are widely used in agriculture and have considerable benefits by contributing to a sustainable production of food and feed. If used improperly or in an inappropriate manner, they also can present unacceptable risks to human and animal health and to the environment.
The OECD Advisory Group on Endocrine Disrupters Testing and Assessment met on 16-17 October 2014 in Paris to discuss the development and update of Test Guidelines and related documents for endocrine disrupters testing and assessment.
The OECD has published a report on a pilot chemical classification exercise undertaken in 2013 and ‘14. Using a number of chemical assessments agreed in the OECD hazard assessment programme, reasons why classification proposals may differ were investigated. The report concludes on the main reasons for such differences, and recommends some measures to overcome some of them.
On 26 September 2014, the OECD Council adopted three new, five updated and one corrected OECD Test Guidelines for the testing of chemicals.
This Test Guideline is a screening method for the evaluation of ready biodegradability of chemicals.
The test substance, normally at 20 mg C/L, as the sole source of carbon and energy, is incubated (during 28 days normally) in sealed bottles with aerobic condition containing a buffer-mineral salts medium, which has been inoculated with a mixed population of micro-organisms. In order to check the test procedure, a reference substance (aniline, sodium benzoate or ethylene glycol and 1-octanol) of known biodegradability should be tested in parallel. It is recommended that triplicate bottles be analysed after a sufficient number of time intervals. Also at least five test bottles (from test vessels, blank controls, and vessels with the reference substance) are analysed at the end of the test, to enable 95% confidence intervals to be calculated for the mean percentage biodegradation value. The CO2 evolution resulting from the ultimate aerobic biodegradation of the test substance is determined by measuring the Inorganic Carbon (IC) produced in the test bottles in excess of that produced in blank vessels containing inoculated medium only. The extent of biodegradation is expressed as a percentage of the theoretical maximum IC production (ThIC), based on the quantity of test substance added initially. Biodegradation >60% ThIC within the 10-d window in this test demonstrates that the test substance is readily biodegradable under aerobic conditions.
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This advisory document provides guidance on how pathology peer reviews should be planned, conducted and reported within the context of OECD Good Laboratory Practice.