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  • 16-September-2020

    English

    OECD Test Guidelines for the Chemicals

    16 September @14:00 CEST | This webinar is organised jointly by the EU funded Projects: NanoHarmony and NANOMET-OECD. Find out how Test Guidelines are developed through the OECD, with case studies from the Test Guidelines being supported through the projects for expansion into nanomaterials.

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  • 31-August-2020

    English

    Intellectual Property elements in OECD Test Guidelines

    The Test Guidelines Programme regularly receives proposals for new and innovative test methods for chemical safety testing. These methods may contain elements protected by intellectual property. The OECD wishes to collect feedback to develop a policy to deal with confidentiality claims so that it remains an attractive programme for innovative methods, while ensuring that developers identify other means to protect their assets.

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  • 7-August-2020

    English

    Pesticides publications (Chronological order)

    Two new reports have been released in the Series on Pesticides: A Guidance Document for the Assessment of the Equivalence of Technical Grade Active Ingredients for Identical Microbial Strains and a Guidance Document on Residues in Rotational Crops.

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  • 4-August-2020

    English

    OECD Work Related to Bees/Pollinators

    There have been reports these last years of declines in native and managed pollinators in several regions of the world. Potential factors associated with these declines are hypothesised to include habitat destruction, predators, certain agricultural practices, bee management practices, pathogens, climate change, nutrition and pesticides. There is uncertainty regarding the extent to which pesticides contribute to pollinator declines.

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  • 20-July-2020

    English

    Series on Testing and Assessment: publications by number

    OECD releases two guidance documents supporting the testing of nanomaterials (MNs). The Guidance Document No. 318 provides guidance for the methods to address dissolution rate and dispersion stability for MNs with focus on environmental aqueous media. The Guidance Document No. 317 provides guidance for aquatic (including sediment) ecotoxicity testing of MNs for the purposes of determining their hazard.

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  • 29-June-2020

    English

    Test No. 405: Acute Eye Irritation/Corrosion

    This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is applied in a single dose in the conjunctival sac of one eye of each animal. The other eye, which remains untreated, serves as a control. The initial test uses an animal; the dose level depends on the test substance nature. A confirmatory test should be made if a corrosive effect is not observed in the initial test, the irritant or negative response should be confirmed using up to two additional animals. It is recommended that it be conducted in a sequential manner in one animal at a time, rather than exposing the two additional animals simultaneously. The duration of the observation period should be sufficient to evaluate fully the magnitude and reversibility of the effects observed. The eyes should be examined at 1, 24, 48, and 72 hours after test substance application. The ocular irritation scores should be evaluated in conjunction with the nature and severity of lesions, and their reversibility or lack of reversibility. Use of topical anesthetics and systemic analgesics to avoid or minimize pain and distress in ocular safety testing procedures is described.
  • 29-June-2020

    English

    Test No. 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals

    This Test Guideline describes in vitro assays, which use Androgen Receptor TransActivation (ARTA) to detect Androgen Receptor Agonists and Antagonists. The ARTA assay methods are mechanistically and functionally similar test methods that provide information on the transcription and translation of a reporter gene following the binding of a chemical to the androgen receptor and subsequent transactivation. The cell lines used in these assays express AR and have been stably transfected with an AR-responsive luciferase reporter gene, and are used to identify chemicals that activate (i.e. act as agonist) or inhibit (i.e. act as antagonists) AR-dependent transcription. Some chemicals may, in a cell type-dependent manner, display both agonist and antagonist activity and are known as selective AR modulators. The AR is activated following ligand binding, after which the receptor-ligand complex binds to specific DNA responsive elements and transactivates the receptor gene, resulting in an increase cellular expression of the luciferase enzyme. The enzyme then transforms the substrate to a bioluminescent product that can be quantitatively measured with a luminometer. This Test Guideline includes ARTA assays using the AR-EcoScreenTM cell line, the AR-CALUX® cell line, and 22Rv1/MMTV_GR-KO cell line.
  • 29-June-2020

    English

    Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

    This Test Guideline describes a cytotoxicity-based in vitro assay that is performed on a confluent monolayer of Statens Seruminstitut Rabbit Cornea (SIRC) cells, cultured on a 96-well polycarbonate microplate. After five-minute exposure to a test chemical, the cytotoxicity is quantitatively measured as the relative viability of SIRC cells using the MTT assay. Decreased cell viability is used to predict potential adverse effects leading to ocular damage. Cell viability is assessed by the quantitative measurement, after extraction from the cells, of blue formazan salt produced by the living cells by enzymatic conversion of the vital dye MTT, also known as Thiazolyl Blue Tetrazolium Bromide. The obtained cell viability is compared to the solvent control (relative viability) and used to estimate the potential eye hazard of the test chemical. A test chemical is classified as UN GHS Category 1 when both the 5% and 0.05% concentrations result in a cell viability smaller than or equal to (≤) 70%. Conversely, a chemical is predicted as UN GHS No Category when both 5% and 0.05% concentrations result in a cell viability higher than (>) 70%.
  • 25-June-2020

    English

    Emergency responses for the supply of disinfectants against Covid-19

    The COVID-19 pandemic calls for urgent policy responses to support the supply of disinfectant products such as hand sanitisers and wipes. The OECD is collecting and providing available information in countries to manage the emergency supply to increase availability of disinfectant products from different competent authorities and industry organisations.

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  • 22-June-2020

    English

    OECD Biotechnology Update

    Read our newsletter to stay up-to-date with all the latest OECD work on biotechnology.

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