Latest Documents


  • 7-November-2017

    English

    Draft Guidance and Review Documents/Monographs

    Three Draft Revised Guidance Documents are open for public comments until September 2017 on Good in Vitro Method 2 Practices (GIVIMP); on Standardised Test Guidelines for 8 Evaluating Chemicals for Endocrine Disruption; and on Aqueous-phase Aquatic Toxicity Testing of Difficult to Test Substances and on Residues in Rotational Crops.

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  • 31-October-2017

    English

    Best Available Techniques to Prevent and Control Industrial Chemical Pollution

    The OECD assist governments to implement policies and practices that embody Best Available Techniques (or similar concepts) to prevent and control industrial emissions.

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  • 31-October-2017

    English

    Environment, Health and Safety News

    The November Chemical Safety newsletter provides an update on the recent events and activities of the OECD Environment, Health and Safety Programme.

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  • 23-October-2017

    English

    Integrated Approaches to Testing and Assessment (IATA)

    Five case studies reviewed in the second review cycle (2016) of the IATA Case Studies Project were published along with a considerations document highlighting the lessons and learnings stemming from the case studies.

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  • 20-October-2017

    English

    Section 4: Health Effects

    New deadlines for comments on the Test Guideline 414: Prenatal Developmental Toxicity Study by 24 November 2017.

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  • 16-October-2017

    English

    OECD Work Related to Endocrine Disrupters

    The OECD Environment, Safety and Health Programme takes actions to develop tools and relevant guidance to identify endocrine disrupting chemicals for the protection of human health and the environment. Based on scientific works and research efforts, standardised test methods can be adopted by OECD countries to detect and characterise hazards posed by endocrine disrupting chemicals.

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  • 13-October-2017

    English

    OECD Guidelines for the Testing of Chemicals

    The OECD Guidelines for the Testing of Chemicals are a collection of the most relevant internationally agreed test methods used by government, industry and independent laboratories to determine the safety of chemicals and chemical preparations, including pesticides and industrial chemicals.

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  • 9-October-2017

    English

    Test No. 405: Acute Eye Irritation/Corrosion

    This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is applied in a single dose in the conjunctival sac of one eye of each animal. The other eye, which remains untreated, serves as a control. The initial test uses an animal; the dose level depends on the test substance nature. A confirmatory test should be made if a corrosive effect is not observed in the initial test, the irritant or negative response should be confirmed using up to two additional animals. It is recommended that it be conducted in a sequential manner in one animal at a time, rather than exposing the two additional animals simultaneously. The duration of the observation period should be sufficient to evaluate fully the magnitude and reversibility of the effects observed. The eyes should be examined at 1, 24, 48, and 72 hours after test substance application. The ocular irritation scores should be evaluated in conjunction with the nature and severity of lesions, and their reversibility or lack of reversibility. Use of topical anesthetics and systemic analgesics to avoid or minimize pain and distress in ocular safety testing procedures is described.

  • 9-October-2017

    English

    Test No. 244: Protozoan Activated Sludge Inhibition Test

    This Test Guideline describes a method to assess effects of a test chemical on the phagocytotic activity of activated sludge containing protozoan organisms under defined conditions in the presence of different concentrations of the test chemical. The principle of biological sewage-treatment plants (STP) is to transform the organic matter of incoming waste-water in microbial biomass, which in turn is separated from the liquid yielding a purified effluent. The purpose of the test is to provide a means to record effects of test chemicals on ciliated protozoa in sewage treatment plants, which due to their grazing on bacteria considerably contribute to the functioning of STPs.
  • 9-October-2017

    English

    Test No. 318: Dispersion Stability of Nanomaterials in Simulated Environmental Media

    This test guideline describes a test procedure to gain information on dispersion stability of manufactured nanomaterials in simulated environmental media. The main purpose of this guideline is to assess the ability of a nanomaterial to attain a colloidal dispersion and to conserve this dispersion under environmentally relevant conditions. The test procedure involves a dispersion of the nanomaterial with the aid of a calibrated sonication procedure and the determination of the mass concentration of the nanomaterial in a set of test vials while the particles undergo homoagglomeration and settling in environments of different hydrochemistry

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