By Date


  • 28-July-2015

    English

    Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists

    This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays). It comprises mechanistically and functionally similar test methods for the identification of estrogen receptor agonists and antagonists and should facilitate the development of new similar or modified test methods. The two reference test methods that provide the basis for this PBTG are: the Stably Transfected TA (STTA) assay using the (h) ERα-HeLa-9903 cell line, derived from a human cervical tumor, and the BG1Luc ER TA assay using the BG1Luc-4E2 cell line, derived from a human ovarian adenocarcinoma. The cell lines used in these assays express ER and have been stably transfected with an ER responsive luciferase reporter gene. The assays are used to identify chemicals that activate (i.e. act as agonists) and also suppress (i.e. act as antagonists) ER- dependent transcription. ER are activated following ligand binding, after which the receptor-ligand complex binds to specific DNA response elements and transactivates the reporter gene, resulting in increased cellular expression of a marker enzyme (e.g. luciferase in luciferase based systems). The enzyme then transforms the substrate to a bioluminescent product that can be quantitatively measured with a luminometer. These test methods are being proposed for screening and prioritisation purposes, but also provide mechanistic information that can be used in a weight of evidence approach.

  • 23-July-2015

    English

    Biological pesticides

    The programme (or BioPesticides including microbials - bacteria, algae, protozoa viruses, fungi -, pheromones and semiochemicals, macrobials/invertebrates such as insects and nematodes, and plant extracts/botanicals) helps member countries to harmonise the methods and approaches used to assess biological pesticides.

    Related Documents
  • 17-June-2015

    English

    eChemPortal: Global Portal to Information on Chemical Substances

    An internet gateway providing direct free access to information on the properties of chemicals as well as to hazard and risk assessments. eChemPortal for access to health and environmental effects information prepared for government chemical review programs around the world. The new brochure is now available and highlights relevant information on the Portal.

    Related Documents
  • 17-June-2015

    English

    Harmonized Tiered Approach to Measure and Assess the Potential Exposure to Airborne Emissions of Engineered Nano-Objects and their Agglomerates and Aggregates at Workplaces

    Engineered nano-objects and their agglomerates and aggregates are handled today in workplaces that span broad occupational environments. The three-tiered approach described in this document is not intended to be a risk assessment strategy, but part of a risk management and mitigation strategy.

    Related Documents
  • 15-June-2015

    English

    OECD improves access to information on the classification of chemicals

    The OECD eChemPortal, a web portal which offers comprehensive information on chemical substances, has been updated to offer better access to chemical classifications according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).

    Related Documents
  • 9-June-2015

    English

    OECD chemical studies show way forward for nanomaterial safety

    Today the OECD marks the end of a seven year experimental testing programme, investigating 11 commercially viable nanomaterials across 110 chemical tests. The results were co-ordinated across 11 countries with tests and data generated from government agencies, universities, research institutions and businesses. Over 780 studies on the specific properties of nanomaterials were undertaken.

    Related Documents
  • 12-May-2015

    English

    IOMC Online Toolbox for Implementing Chemical Safety

    The new version of the IOMC Toolbox for Decision Making in Chemicals Management provides a set of interactive features allowing governments to use it as a platform for collaboration among ministries, agencies, and other stakeholders such as industry. Users can save their information, add comments, and share and discuss issues with colleagues and partners.

    Related Documents
  • 23-April-2015

    English

    Safety Assessment of Foods and Feeds Derived from Transgenic Crops, Volume 2

    Volume II of this series compiles the science-based consensus documents of the OECD Task Force for the Safety of Novel Foods and Feeds from 2009 to 2014. They contain information for use during the regulatory assessment of food/feed products of modern biotechnology, i.e. developed from transgenic crops. Relevant information includes compositional considerations (nutrients, anti-nutrients, toxicants, allergens), use of the plant species as food/feed, key products and components suggested for analysis of new varieties for food use and for feed use, and other elements. These documents should be of value to applicants for commercial uses of novel foods and feeds, regulators and risk assessors in national authorities for their comparative approach, as well as the wider scientific community.

  • 3-April-2015

    English

    Emission Scenario Document (ESD) On Chemical Vapour Deposition In The Semiconductor Industry

    The Emission Scenario Document (ESD) is intended to provide information on the sources, use patterns, and potential release pathways of chemicals used as chemical vapour deposition (CVD) precursors in the semiconductor industry. The document presents standard approaches for estimating environmental releases and occupational exposures, and discusses the typical engineering controls used to mitigate exposure to CVD precursors.

    Related Documents
  • 3-April-2015

    English

    Emission Scenario Document (ESD) On The Use Of Adhesives

    This OECD Emission Scenario Document (ESD) is intended to provide information on the sources, use patterns, and potential release pathways of chemicals used in adhesive products, specifically during the use of adhesives in various industries.

    Related Documents
  • << < 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 > >>