By Date


  • 23-September-2015

    English

    Corporate governance for process safety: Guidance for senior leaders in high hazard industries

    This guidance document for senior leaders in high hazard industries on Corporate Governance for Process Safety is available in 11 languages (now including Czech). It aims to strike a balance between risk and benefit by drawing the attention of those at the top of industry to the need for high standards of corporate governance in relation to the management of high hazard industries.

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  • 20-August-2015

    English

    Preliminary guidance notes on Nanomaterials: Interspecies variability factors in human health risk assessment

    This document gives a recommendations on the Use of Assessment Factors for Intra- and Interspecies Differences in Human Health Risk Assessment of Nanomaterials.

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  • 7-August-2015

    English

    Biocides

    The objective of the OECD Biocide Programme is to attain a harmonised approach in the regulation of biocides in all OECD countries. The OECD is thus working on harmonising the main data requirements for biocides and the methodologies for the interpretation of these data.

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  • 7-August-2015

    English

    Agricultural Pesticides

    The Pesticide Programme of the OECD looks to help governments co-operate in assessing and reducing the risks of agricultural pesticides. The OECD encourages governments to share the work of pesticide registration and develops tools to monitor and minimise pesticide risk to health and the environment.

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  • 7-August-2015

    English

    Introduction to Pollutant Release and Transfer Registers (PRTRs)

    An introduction to Pollutant Release and Transfer Registers (PRTRs) including an explanation of what they are as well as the role of stakeholders, including industry, the public, NGOs and the scientific and economic communities, as well as government.

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  • 7-August-2015

    English

    The chemical accidents programme

    The OECD Programme on Chemical Accidents addresses a subject that concerns everyone who uses or handles hazardous chemicals, works in a chemical plant, or lives near one. This programme helps public authorities, industry, labour and other interested parties prevent chemical accidents and respond appropriately if one occurs.

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  • 31-July-2015

    English

    OECD biotechnology newsletter updates

    OECD major events and activities relating to biotechnologies: latest developments are updated biannually in this Newsletter.

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  • 28-July-2015

    English

    Newly published set of Test Guidelines

    A set of new and updated OECD Test Guidelines was published at the end of July 2015 to test chemicals and identify hazards such as endocrine disruption, serious eye damage, genotoxicity, skin irritation or corrosion.

  • 28-July-2015

    English, PDF, 771kb

    Draft Updated Test Guideline 223: Avian Acute Oral Toxicity Test

    This Test Guideline describes procedures designed to estimate the acute oral toxicity of substances to birds, and it provides three testing options: (1) limit dose test, (2) LD50-slope test, and (3) LD50-only test.

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  • 28-July-2015

    English

    Test No. 241: The Larval Amphibian Growth and Development Assay (LAGDA)

    The test guideline of the Larval Amphibian Growth and Development Assay (LAGDA) describes a toxicity test with an amphibian species (African clawed frog (Xenopus laevis)) that considers growth and development from fertilization through the early juvenile period.  It is an assay (typically 16 weeks) that assesses early development, metamorphosis, survival, growth, and partial reproductive maturation. It also enables measurement of a suite of other endpoints that allows for diagnostic evaluation of suspected endocrine disrupting chemicals (EDCs) or other types of developmental and reproductive toxicants. The LAGDA serves as a higher tier test with an amphibian for collecting more comprehensive concentration-response information on adverse effects suitable for use in hazard identification and characterization, and in ecological risk assessment. The general experimental design entails exposing X. laevis embryos at Nieuwkoop and Faber (NF) stage 8-10 (3) to a minimum of four different concentrations of test chemical and control(s) until 10 weeks after the median time to NF stage 62.  There are four replicates in each test concentration with eight replicates for the control. Endpoints evaluated during the course of the exposure (at the interim sub-sample and final sample at completion of the test) include those indicative of generalized toxicity: mortality, abnormal behaviour, and growth determinations (length and weight), as well as endpoints designed to characterize specific endocrine toxicity modes of action targeting oestrogen, androgen or thyroid-mediated physiological processes.

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