In a developmental neurotoxicity study (MRID [number if available]) [Chemical name (% a.i.)] was administered to [# of animals] female [strain] rats per dose in [by gavage, diet, water, inhalation] at dose levels of 0, x, x, or x mg/kg bw/day from gestation day [#] through postnatal day [#]. (Briefly describe study procedures. Mention all critical and/or unusual procedures, e.g., direct treatment of offspring, neurobehavioral and neuropathology assessments, biochemical measures, etc.)
[Concisely describe treatment-related toxicity, at the LOAEL and at doses greater than the LOAEL, for both dams and offspring. Do not attempt to separate systemic- and developmental-neurotoxicity; it is not possible to make this type of distinction based on the data available in these studies. If no toxicity was observed, state that there were no treatment-related effects, for maternal animals and/or offspring as appropriate.]
The maternal LOAEL is [dose] mg/kg bw/day, based on [endpoint]. The maternal NOAEL is [dose] mg/kg bw/day.
The offspring LOAEL is [dose] mg/kg bw/day, based on [endpoint]. The offspring NOAEL is [dose] mg/kg bw/day.
[If applicable; list separately for maternal and offspring endpoints when available:]
The LOAEL for plasma cholinesterase inhibition is [dose] mg/kg bw/day, with a NOAEL of [dose] mg/kg bw/day.
The LOAEL for erythrocyte cholinesterase inhibition is [dose] mg/kg bw/day, with a NOAEL of [dose] mg/kg bw/day.
The LOAEL for brain cholinesterase inhibition is [dose] mg/kg bw/day, with a NOAEL of [dose] mg/kg bw/day.