In a combined chronic / carcinogenicity study (MRID  if available), [Chemical name, % a.i.] was administered to [(# of animals) species, strain]/sex/dose in [diet, water, by gavage] at dose levels of 0, x, x, x ppm (0, x, x, x mg/kg bw/day) for (duration).

 

[Describe toxicity briefly.  If no toxicity state that there were no compound related effects in mortality, clinical signs, body weight, food consumption, hematology, clinical chemistry, urinalysis, organ weights, or gross and histologic pathology]The LOAEL is      , based on           .  The NOAEL is    .

 

At the doses tested, there was (not) a treatment related increase in tumor incidence [specify tumor type] when compared to controls. (brief description).  Dosing was (not) considered adequate based on (mention critical endpoint noted above).

 

This chronic/carcinogenicity study in the (species) is [acceptable, unacceptable (why)] and satisfies and satisfies (does not satisfy) the guideline requirement for a chronic/carcinogenicity study (OPPTS 870.4300); OECD 453 in [species]. [If it does not satisfy the requirement, concisely list only major deficiencies or refer to deficiency section.]