S             species

-              doses, group size, application area and total surface area

-              exposure and monitoring times

-              specify dermal absorption value at each dose, noting time of skin wash and time of sacrifice)

-              indicate the most appropriate dermal absorption value

-              comment on the role of duration and dose level in selecting the most appropriate value

-              additional comments as applicable (e.g., residues retained at the skin site, etc.)



(e.g. , Male Charles River rats were administered nominal doses of 0.00X, 0.0X or 0.X mg/cm2 of [test substance] in [vehicle and its volume] and monitored up to 120 hr  post-dosing.  Mean dermal absorption values,  for the  groups for which the skin site was washed after 10 hours with sacrifice at 120 hrs (n=4), were X%, Y% and Z% respectively  at the three dose levels.  Ten hours is considered most applicable to the typical worker exposure time.  If the typical worker dose is not known, it would be appropriate to utilise the low dose dermal absorption value to be conservative in risk assessment.  These values are  considered conservative because a portion of the active ingredient was retained at the skin site and it is unlikely that all of the skin residues will become systemically available.)