Table #: Gross necropsy and tissue preparation (checked (X) collected (column C), weighed (column W) and
examined for histopathology (column H with X = all groups, # = control and top dose animals as well as all low
and mid dose animals which died prematurely or were sacrificed moribund)

Pathology:

C

W

H

C

W

H

C

W

H

Adrenal glands

Liver

Stomach

Aorta

Lung

Testis

Bile duct

Lymph nodes#

Thymus

Brain*

Female mammary gland

Thyroid/parathyroid

Bone marrow

Muscle, skeletal

Tongue

Caecum

Nasal cavity (Level I IV)

Trachea

Colon

Nerve, peripheral (sciatic n.)

Urinary bladder

Duodenum

Ovary and oviduct

Uterus

Epididymides

Pancreas

Vagina

Esophagus

Pituitary

Others:

Eyes (with optic nerve)

Pharynx

Body (exsanguinated)

Femur (with joint)

Prostate

Gall bladder (mouse and dog)

Rectum

Gross lesions/masses

Salivary glands (mandibular, sublingual)

Heart

Seminal vesicles

Ileum

Skin/subcutis

Jejunum

Spinal cord (3 levels)@

Kidneys

Spleen

Lachrymal glands

Sternum

Larynx (Level I III)

Sternum

* histopathological examination of medulla, cerebral cortex, cerebellar cortex; from femur and sternum, histopathology of sternum bone marrow only; # mediastinal and mesenteric; @ cervical, thoracic, lumbar)