Table #: Functional observational battery (The CHECKED (X) parameters were examined.)

X

HOME CAGE OBSERVATIONS

X

HANDLING OBSERVATIONS

X

OPEN FIELD OBSERVATIONS

 

Posture*

 

Reactivity*

 

Mobility

 

Biting

 

Lacrimation* / chromodacryorrhea

 

Rearing+

 

Convulsions*

 

Salivation*

 

Arousal/ gereral activity level*

 

Tremors*

 

Piloerection*

 

Convulsions

 

Abnormal Movements*

 

Fur appearance

 

Tremors*

 

Palpebral closure*

 

Palpebral closure*

 

Abnormal movements

 

Faeces consistency

 

Respiratory rate+

 

Urination / defecation*

 

 

 

Red/crusty deposits*

 

Grooming

 

SENSORY OBSERVATIONS

 

Mucous membranes /eye /skin colour

 

Gait abnormalities / posture*

 

Approach response+

 

Eye prominence*

 

Gait score*

 

Touch response+

 

Muscle tone*

 

Bizarre / stereotypic behaviour*

 

Startle response*

 

 

 

Backing

 

Pain response*

 

 

 

Time to first step

 

Pupil response*

 

 

 

 

 

Eyeblink response

 

PHYSIOLOGICAL OBSERVATIONS

 

NEUROMUSCULAR OBSERVATIONS

 

Forelimb extension

 

Body weight*

 

Hindlimb extensor strength

 

Hindlimb extension

 

Body temperature+

 

Forelimb grip strength*

 

Air righting reflex+

 

 

 

Hindlimb grip strength*

 

Olfactory orientation

 

 

 

Hindlimb foot splay*

 

 

 

OTHER OBSERVATIONS

 

Rotarod performance

 

 

 

 

 

 

 

*Required parameters; +Recommended parameters