Table #: Gross necropsy and tissue preparation of parent, F1 and F2 animals (checked (X) collected (column C), weighed (column W) and
examined for histopathology (column H with X = all groups, # = control and top dose animals as well as all low and mid dose animals
which died prematurely or were sacrificed moribund; or indicate dose levels)

P (Parents)

F1

F2

C

W

H

SYSTEM

C

W

H

SYSTEM

C

W

H

SYSTEM

 

 

 

digestive

 

 

 

digestive

 

 

 

digestive

 

 

 

Liver

 

 

 

Liver

 

 

 

Liver

 

 

 

Stomach

 

 

 

Stomach

 

 

 

Stomach

 

 

 

reticulo- endothelial
hematopoietic

 

 

 

reticulo- endothelial
hematopoietic

 

 

 

reticulo- endothelial
hematopoietic

 

 

 

Bone marrow§

 

 

 

Bone marrow§

 

 

 

Bone marrow§

 

 

 

Lymph nodes

 

 

 

Lymph nodes

 

 

 

Lymph nodes

 

 

 

Peyer’s patch

 

 

 

Peyer’s patch

 

 

 

Peyer’s patch

 

 

 

Spleen

 

 

 

Spleen

 

 

 

Spleen

 

 

 

Thymus

 

 

 

Thymus

 

 

 

Thymus

 

 

 

urogenital

 

 

 

urogenital

 

 

 

urogenital

 

 

 

Epididymis

 

 

 

Epididymis

 

 

 

Epididymis

 

 

 

Kidneys

 

 

 

Kidneys

 

 

 

Kidneys

 

 

 

Ovaries

 

 

 

Ovaries

 

 

 

Ovaries

 

 

 

Primordial follicles, growing follicles, and large Corpora lutea of lactation from the post-lactation ovary

 

 

 

Primordial follicles, growing follicles, and large Corpora lutea of lactation from the post-lactation ovary

 

 

 

Primordial follicles, growing follicles, and large Corpora lutea of lactation from the post-lactation ovary

 

 

 

Prostate

 

 

 

Prostate

 

 

 

Prostate

 

 

 

Seminal Vesicle with Coagulating Gland (if present)

 

 

 

Seminal Vesicle with Coagulating Gland (if present)

 

 

 

Seminal Vesicle with Coagulating Gland (if present)

 

 

 

Testes

 

 

 

Testes

 

 

 

Testes

 

 

 

Uterus (with oviducts)

 

 

 

Uterus (with oviducts)

 

 

 

Uterus (with oviducts)

 

 

 

Vagina

 

 

 

Vagina

 

 

 

Vagina

 

 

 

neurologic

 

 

 

neurologic

 

 

 

neurologic

 

 

 

Brain (at least 3 different levels)

 

 

 

Brain (at least 3 different levels)

 

 

 

Brain (at least 3 different levels)

 

 

 

Peripheral nerve tissue

 

 

 

Peripheral nerve tissue

 

 

 

Peripheral nerve tissue

 

 

 

Spinal cord (at least 2 different locations)

 

 

 

Spinal cord (at least 2 different locations)

 

 

 

Spinal cord (at least 2 different locations)

 

 

 

glandular

 

 

 

glandular

 

 

 

glandular

 

 

 

Adrenal glands

 

 

 

Adrenal glands

 

 

 

Adrenal glands

 

 

 

Pituitary gland

 

 

 

Pituitary gland

 

 

 

Pituitary gland

 

 

 

other

 

 

 

other

 

 

 

other

 

 

 

Target organ:

 

 

 

Target organ:

 

 

 

Target organ: