Table #: Gross necropsy and tissue preparation of parent, F1 and F2 animals (checked (X) collected (column C), weighed (column W) and
examined for histopathology (column H with X = all groups, # = control and top dose animals as well as all low and mid dose animals
which died prematurely or were sacrificed moribund; or indicate dose levels)
| P (Parents) | F1 | F2 | |||||||||
| C | W | H | SYSTEM | C | W | H | SYSTEM | C | W | H | SYSTEM |
|
|
|
| digestive |
|
|
| digestive |
|
|
| digestive |
|
|
|
| Liver |
|
|
| Liver |
|
|
| Liver |
|
|
|
| Stomach |
|
|
| Stomach |
|
|
| Stomach |
|
|
|
| reticulo- endothelial |
|
|
| reticulo- endothelial |
|
|
| reticulo- endothelial |
|
|
|
| Bone marrow§ |
|
|
| Bone marrow§ |
|
|
| Bone marrow§ |
|
|
|
| Lymph nodes |
|
|
| Lymph nodes |
|
|
| Lymph nodes |
|
|
|
| Peyer’s patch |
|
|
| Peyer’s patch |
|
|
| Peyer’s patch |
|
|
|
| Spleen |
|
|
| Spleen |
|
|
| Spleen |
|
|
|
| Thymus |
|
|
| Thymus |
|
|
| Thymus |
|
|
|
| urogenital |
|
|
| urogenital |
|
|
| urogenital |
|
|
|
| Epididymis |
|
|
| Epididymis |
|
|
| Epididymis |
|
|
|
| Kidneys |
|
|
| Kidneys |
|
|
| Kidneys |
|
|
|
| Ovaries |
|
|
| Ovaries |
|
|
| Ovaries |
|
|
|
| Primordial follicles, growing follicles, and large Corpora lutea of lactation from the post-lactation ovary |
|
|
| Primordial follicles, growing follicles, and large Corpora lutea of lactation from the post-lactation ovary |
|
|
| Primordial follicles, growing follicles, and large Corpora lutea of lactation from the post-lactation ovary |
|
|
|
| Prostate |
|
|
| Prostate |
|
|
| Prostate |
|
|
|
| Seminal Vesicle with Coagulating Gland (if present) |
|
|
| Seminal Vesicle with Coagulating Gland (if present) |
|
|
| Seminal Vesicle with Coagulating Gland (if present) |
|
|
|
| Testes |
|
|
| Testes |
|
|
| Testes |
|
|
|
| Uterus (with oviducts) |
|
|
| Uterus (with oviducts) |
|
|
| Uterus (with oviducts) |
|
|
|
| Vagina |
|
|
| Vagina |
|
|
| Vagina |
|
|
|
| neurologic |
|
|
| neurologic |
|
|
| neurologic |
|
|
|
| Brain (at least 3 different levels) |
|
|
| Brain (at least 3 different levels) |
|
|
| Brain (at least 3 different levels) |
|
|
|
| Peripheral nerve tissue |
|
|
| Peripheral nerve tissue |
|
|
| Peripheral nerve tissue |
|
|
|
| Spinal cord (at least 2 different locations) |
|
|
| Spinal cord (at least 2 different locations) |
|
|
| Spinal cord (at least 2 different locations) |
|
|
|
| glandular |
|
|
| glandular |
|
|
| glandular |
|
|
|
| Adrenal glands |
|
|
| Adrenal glands |
|
|
| Adrenal glands |
|
|
|
| Pituitary gland |
|
|
| Pituitary gland |
|
|
| Pituitary gland |
|
|
|
| other |
|
|
| other |
|
|
| other |
|
|
|
| Target organ: |
|
|
| Target organ: |
|
|
| Target organ: |
|
|
|
|
|
|
|
|
|
|
|
|
|