Table #: Selected haematology, clinical chemistry and pathology findings

Doses (unit)

0

x

xx

xxx

0

x

xx

xxx

male

female

Number of animals/group

10

10

10

10

10

10

10

10

Haematology (day x)

 

 

 

 

 

 

 

 

- RBC (TERA/L)

 

 

 

 

 

 

 

 

- MCV (FL)

 

 

 

 

 

 

 

 

- HCT (L/L)

 

 

 

 

 

 

 

 

- HGB (MMOL/L)

 

 

 

 

 

 

 

 

- WBC (GIGA/L)

 

 

 

 

 

 

 

 

Blood chemistry (day x)

 

 

 

 

 

 

 

 

- sodium (MMOL/L)

 

 

 

 

 

 

 

 

- potassium (MMOL/L)

 

 

 

 

 

 

 

 

- chloride (MMOL/L)

 

 

 

 

 

 

 

 

- gobulin (G/L)

 

 

 

 

 

 

 

 

- cholesterol (MMOL/L)

 

 

 

 

 

 

 

 

- triglyceride (MMOL/L)

 

 

 

 

 

 

 

 

Pathology

 

 

 

 

 

 

 

 

Liver – focus

 

 

 

 

 

 

 

 

- cloudy swelling

 

 

 

 

 

 

 

 

- single cell necrosis

 

 

 

 

 

 

 

 

- hepatocellular alteration

 

 

 

 

 

 

 

 

Testes - Leydig cell hyperplasia

 

 

 

 

 

 

 

 

Adrenal glands – enlargement

 

 

 

 

 

 

 

 

- discolouration

 

 

 

 

 

 

 

 

- hypertrophy z. fasciculata

 

 

 

 

 

 

 

 

- vacuolation, z. fasciculata

 

 

 

 

 

 

 

 

Pituitary - cystic degeneration

 

 

 

 

 

 

 

 

Pancreas –acinar vacuolation

 

 

 

 

 

 

 

 

- islet cell hyperplasia

 

 

 

 

 

 

 

 

Ovary, luteal cell vacuolation

 

 

 

 

 

 

 

 

Eye – cataract

 

 

 

 

 

 

 

 

Lung

 

 

 

 

 

 

 

 

Skin

 

 

 

 

 

 

 

 

Statistics: Anova + Dunnetts tests (two sided): * P,0.05   ** P,0.01