Table #: Gross necropsy and tissue preparation (checked (X) collected (column C), weighed (column W) and
examined for histopathology (column H with X = all groups, # = control and top dose animals as well as all low
and mid dose animals which died prematurely or were sacrificed moribund)
| Pathology: | |||||||||||
| C | W | H |
| C | W | H |
| C | W | H |
|
|
|
|
| Adrenal glands |
|
|
| Liver |
|
|
| Stomach |
|
|
|
| Aorta |
|
|
| Lung |
|
|
| Testis |
|
|
|
| Bile duct |
|
|
| Lymph nodes# |
|
|
| Thymus |
|
|
|
| Brain* |
|
|
| Female mammary gland |
|
|
| Thyroid/parathyroid |
|
|
|
| Bone marrow§ |
|
|
| Muscle, skeletal |
|
|
| Tongue |
|
|
|
| Caecum |
|
|
| Nasal cavity (Level I – IV) |
|
|
| Trachea |
|
|
|
| Colon |
|
|
| Nerve, peripheral (sciatic n.) |
|
|
| Urinary bladder |
|
|
|
| Duodenum |
|
|
| Ovary and oviduct |
|
|
| Uterus |
|
|
|
| Epididymides |
|
|
| Pancreas |
|
|
| Vagina |
|
|
|
| Esophagus |
|
|
| Pituitary |
|
|
| Others: |
|
|
|
| Eyes (with optic nerve) |
|
|
| Pharynx |
|
|
| Body (exsanguinated) |
|
|
|
| Femur (with joint) |
|
|
| Prostate |
|
|
|
|
|
|
|
| Gall bladder (mouse and dog) |
|
|
| Rectum |
|
|
|
|
|
|
|
| Gross lesions/masses |
|
|
| Salivary glands (mandibular, sublingual) |
|
|
|
|
|
|
|
| Heart |
|
|
| Seminal vesicles |
|
|
|
|
|
|
|
| Ileum |
|
|
| Skin/subcutis |
|
|
|
|
|
|
|
| Jejunum |
|
|
| Spinal cord (3 levels)@ |
|
|
|
|
|
|
|
| Kidneys |
|
|
| Spleen |
|
|
|
|
|
|
|
| Lachrymal glands |
|
|
| Sternum |
|
|
|
|
|
|
|
| Larynx (Level I – III) |
|
|
| Sternum |
|
|
|
|
| * histopathological examination of medulla, cerebral cortex, cerebellar cortex; § from femur and sternum, histopathology of sternum bone marrow only; # mediastinal and mesenteric; @ cervical, thoracic, lumbar) | |||||||||||