Table #: Number of animals with gross, non-neoplastic, or neoplastic lesions at end of dosing period or, if indicated by footnote, at earlier time points.
| SEX | males | females | ||||||
| DAILY DOSE | 0 | x | xx | xxx | 0 | x | xx | xxx |
| NUMBER OF ANIMALS EXAMINED |
|
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|
|
|
| DIGESTIVE SYSTEM |
|
|
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|
|
|
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| ORGAN/TISSUE |
|
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|
|
|
|
|
|
| Gross lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Non-neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
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|
|
|
|
|
| Lesion x |
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|
|
| RESPIRATORY SYSTEM |
|
|
|
|
|
|
|
|
| ORGAN/TISSUE |
|
|
|
|
|
|
|
|
| Gross lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Non-neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
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|
|
|
|
|
|
| Lesion x |
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|
| CARDIOVASCULAR SYSTEM |
|
|
|
|
|
|
|
|
| ORGAN/TISSUE |
|
|
|
|
|
|
|
|
| Gross lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Non-neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
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|
|
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|
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|
|
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|
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|
|
|
| RETICULO-ENDOTHELIAL /HEMATOPOIETIC SYSTEM |
|
|
|
|
|
|
|
|
| ORGAN/TISSUE |
|
|
|
|
|
|
|
|
| Gross lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Non-neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
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|
|
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|
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|
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|
| UROGENITAL SYSTEM |
|
|
|
|
|
|
|
|
| ORGAN/TISSUE |
|
|
|
|
|
|
|
|
| Gross lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Non-neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| GLANDULAR SYSTEM |
|
|
|
|
|
|
|
|
| ORGAN/TISSUE |
|
|
|
|
|
|
|
|
| Gross lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Non-neoplastic lesion: |
|
|
|
|
|
|
|
|
| Lesion x |
|
|
|
|
|
|
|
|
| Lesion x |
|
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|
* p<0.05, ** p<0.01