Table #: Selected haematology, clinical chemistry and pathology findings among mice (at termination)

Dose level (Unit)

0

x

xx

xxx

xxxx

0

x

xx

xxx

xxxx

male

female

Number in group

10

10

10

9

9

10

10

10 9

9

Haematology (mean values)

NEU (thousand / mm≥)

LYM (thousand / mm≥)

BAS (thousand / mm≥)

EOS (thousand / mm≥)

Clinical chemistry (mean values)

AP(IU/L)#

AST(IU/L)

Gross pathology (incidence)

Liver - discoloration

Histopathology (incidence)

Liver
††††††† - haemorrhagic necrosis / †††† †††fibrosis

††††††† - necrosis + inflammation

††††††† - mononuclear cell infiltrate

Spleen - excess haematopoiesis

Uterus - hydrometra

* Linearly related to dose (p < 0.05) with a negative scope (females only).

** (p <0.05) and *** <0.01) vs control

# Linearly related to dose (p <0.05) with a positive scope for males and a negative scope for females