Doses (unit)

0

x

xx

xxx

0

x

xx

xxx

male

female

Number of animals/group

10

10

10

10

10

10

10

10

Haematology (day x)

- RBC (TERA/L)

- MCV (FL)

- HCT (L/L)

- HGB (MMOL/L)

- WBC (GIGA/L)

Blood chemistry (day x)

- sodium (MMOL/L)

- potassium (MMOL/L)

- chloride (MMOL/L)

- gobulin (G/L)

- cholesterol (MMOL/L)

- triglyceride (MMOL/L)

Pathology

Liver – focus

- cloudy swelling

- single cell necrosis

- hepatocellular alteration

Testes - Leydig cell hyperplasia

Adrenal glands – enlargement

- discolouration

- hypertrophy z. fasciculata

- vacuolation, z. fasciculata

Pituitary - cystic degeneration

Pancreas –acinar vacuolation

- islet cell hyperplasia

Ovary, luteal cell vacuolation

Eye – cataract

Lung

Skin