The <code>EndpointStudyRecord</code> is used for modelling Endpoints in the flexible model such as containers for 'all endpoint study records', 'all endpoints' or even further <code>EndpointStudyRecord</code> entries. Basically everything that is an entry on the 'hierarchical chapter tree' is represented by a <code>EndpointStudyRecord</code>. <p/>The <code>EndpointStudyRecord</code> can be direct parent for <code>Element</code> objects. The latter are already flexible data objects yet provide no addressing capabilities. Modification tracking of this object - any trackable document needs such a record since the queryLastModified() and similar methods require this structure to be present. An optional modification comment. The party performing the modification. The modification date. This structure defines properies on ownership, authentication of the original author, and authorized uses of the current document. Document ownership code. The document ownership code is a calculated code, e. g. from author's company, plus department or any arbitrary tag. The document ownership field is just an encoded string to prevent additional joins from persistence point of view.

Note: If the document ownership is empty, no ownership is claimed and the current user can open/alter the current document in any way. There would also be need for an additional access control operation: "take ownership".

 If a document originally was filtered during export and thus the data contained within the document is only a subset of the overall, this flag should be set to true. It can be used during import to advise the user if he can safely import the document or should rather take a closer look inside since otherwise data may effectively be lost! Usually no document is sealed and thus can be modified at any time by virtually anybody allowed by the access control. However, there is one big exception: IUCLID5 Agency and management of Dossier documents. Once dossiers have been created, the dossier itself and anything referenced from within is not modifyable anymore - therefore, it can be sealed. Flag that allows or prevents the current document to be copied and pasted. A user-specified name for the endpoint study record. This name is not to be confused with the so called 'default endpoint names' for REACH-IT. It is just a simple name where the user (or later some system automatism) can store text which is displayed in the section tree, the reference tracker, the import/export module, etc. This is the alphanumeric description field which is displayed on screen as indicator where the document reference points to.

Usually this field has to be set when the document reference is created and should carry some clear indication where it points to such as the company name, the substance name, etc.

 This is a free-text field for user convenience to attach additional text to a DocumentReference. Last modification date of the target document. This field is not member of the primary key. Only at dossier creation time, the content of the field is encoded into timeStamp thus virtually creating a snapshot copy of the original object. Type of the target document, accelerates reference resolving. If absent, the resolver will have to look up all 'root element' tables. Unique identifier of the target document

Note: primary key composition. Yet this does not belong to the primary key of the current class since there may be any number of DocumentReference objects pointing to the same document effectively.

This is the alphanumeric description field which is displayed on screen as indicator where the document reference points to.

Usually this field has to be set when the document reference is created and should carry some clear indication where it points to such as the company name, the substance name, etc.

 This is a free-text field for user convenience to attach additional text to a DocumentReference. The endpoint kind of the endpoint this reference points to. This field is not reliable, it may be null although the referenced document carries an 'endpoint kind' of course. Yet not all code might be changed to properly support this.

Also, IUC-468 (sorting) assumes that the 'endpointKind' of the referenced FlexibleEndpoint will never change.

 Last modification date of the target document. This field is not member of the primary key. Only at dossier creation time, the content of the field is encoded into timeStamp thus virtually creating a snapshot copy of the original object. Type of the target document, accelerates reference resolving. If absent, the resolver will have to look up all 'root element' tables. Unique identifier of the target document

Note: primary key composition. Yet this does not belong to the primary key of the current class since there may be any number of DocumentReference objects pointing to the same document effectively.

The target type for the referenced flexible element. the level of data protection == confidentiality intended for the associated data / entities A free-text justification on the current confidentiality setting (see member confidentiality) Pick list <b>N78 </b> <p/>The regulatory purpose which applies: <ul> <li>Canada: Existing Substances Program under CEPA</li> <li>Canada: Pest Control Products Act (PCPA)</li> <li>EU: Biocides Programme</li> <li>EU: Existing Chemicals Programme</li> <li>EU: New Chemicals Programme</li> <li>EU: Registration, Evaluation and Authorisation of Chemicals (REACH)</li> <li>Japan: Chemical Substances Control Law</li> <li>OECD: HPV Chemicals Programme</li> <li>US: EPA HPV Chemical Challenge Programme</li> <li>US: Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)</li> <li>US: Toxic Substances Control Act</li> <li>[other]</li> </ul> the purpose flag the data waiving the justification for the data waiving the study result type the study period the reliablility the rational reliablility [Path: TO_FOOD_METABOLISM_LIVESTOCK.GEN_DATA_SOURCE_HD] [Path: TO_FOOD_METABOLISM_LIVESTOCK.TO_FOOD_METABOLISM_LIVESTOCK] Use this field to include any background information, if required, or any relevant introductory remarks on the study summary. Leave field empty if not applicable. Do not include information for which specific fields are provided. For instance, include any background information on the test substance in fields on "Test materials". [Path: TO_FOOD_METABOLISM_LIVESTOCK.TO_FOOD_METABOLISM_LIVESTOCK.TEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE] Indicate the bibliographic reference of the study report or publication the study summary is based on. Always enter the primary reference in the first block of fields (i.e. Sort no. = 1), if there are more than one reference to be cited. Copy this block of fields for specifying any other references related to this record (e.g. report of a preliminary study or other documentation). If results of a study report have been published, indicate the full citation of that publication(s) in addition to the reference of the original study. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_TYPE] Indicate the type of reference, e.g. "Study report" or "Publication". Select "Other company data" to characterise any unpublished information from a company other than a study report. Select "Grey literature" for any other unpublished information or "other:" and specify. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_TYPE_TXT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_AUTHOR] For ease of sorting and searchability use following convention: Surname, Initial (Example 1: White D, Ruehl KJ, Borman SA & Little J. Example 2: Hartley M & Murray W (avoid unnecessary full-stops, commas)). If no individuals are cited as authors, enter name of company or organisation or "Anon." as appropriate.Note that the complete bibliographic reference may appear in this field after migration of unstructured data from existing databases. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_YEAR] Enter year of study report or publication. For a study report this field should be completed to include it in any searches, regardless of whether the complete date is given in field "Report date". [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_TITLE] Include the title of the report. For publications, include the title of the article of a journal or article/chapter of a book (e.g. handbook). [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_SOURCE] Not relevant for any study report. For publications or any other literature source (grey literature) specify the following type of information: (i) Title of scientific journal or book (e.g. if handbook); (ii) Volume of journal; (iii) Editor, publisher, place of publication for books or articles in books; (iv) Pagination.Example 1 (journal): J. Agric. Food Chem. 38: 215-227Example 2 (handbook): In: Lyman WJ (ed.) Handbook of chemical property estimation methods. Environmental behavior of organic compounds. McGraw-Hill Book Company 15.1-15.34, New York. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_TESTLAB] Either manually enter the name of the testing laboratory or select it from the picklist. In either case, editing is possible. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_REPORT_NO] Specify the report number allocated by the testing laboratory. Note that any company-specific study number should be included in the respective field. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_COMPANY_ID] Either manually enter the identity of the company who owns the data or select it from the picklist. In either case, editing is possible. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_COMPANY_STUDY_NO] Specify any company study no. if there is such a number and if it is different from the report no. of the testing laboratory. Otherwise leave field empty. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REFERENCE.REFERENCE_REPORT_DATE] Specify the complete date of the study report, e.g. "2005-05-12" for 12 May 2005. Note that subfield "Year" should be completed in any case for sorting and searching purposes. [Path: TO_FOOD_METABOLISM_LIVESTOCK.DATA_ACCESS] Select appropriate indication for data access. Enter "Not applicable" if the summary consists of information that is commonly accessible such as guidance on safe use. [Path: TO_FOOD_METABOLISM_LIVESTOCK.DATA_ACCESS.LIST_POP] [Path: TO_FOOD_METABOLISM_LIVESTOCK.DATA_ACCESS.LIST_POP_TXT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.DATA_PROT_CLAIM] Indicate as appropriate. Note: "yes" should be selected only if "Data submitter is data owner" or "Data submitter has Letter of Access". Options "yes, but willing to share" or "yes, but not willing to share" may be relevant for specific regulatory programmes where the submitter is requested to indicate whether he is willing to share studies (e.g. with vertebrates).In the supplementary remarks field, include an explanation as appropriate, i.e. justification for denial of sharing the corresponding study or refer to a document attached that provides justification (e.g. "for justification see attached document X") [Path: TO_FOOD_METABOLISM_LIVESTOCK.DATA_PROT_CLAIM.LIST_POP_FIX] [Path: TO_FOOD_METABOLISM_LIVESTOCK.DATA_PROT_CLAIM.LIST_POP_FIX_TXT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.CROSSREF_SAMESTUDY] A cross-reference can be included to indicate that the same study is recorded in another record. Indicate the respective chapter and record ID and enter relevant explanatory text. This may be useful if specific endpoints of a given study are described in another chapter (e.g. results on reproduction toxicity in case of a combined repeated dose / reproduction toxicity study) or if more than one experiment is described by the same study report, but included in separate records.Check with the relevant guidance document whether all the methodology details must be repeated or whether a cross-reference to the same study in another chapter may suffice.Note that any such cross-reference may become useless if a record is either printed or exchanged on its own. [Path: TO_FOOD_METABOLISM_LIVESTOCK.CROSSREF_SAMESTUDY.TEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.GEN_MAT_ME_HD] [Path: TO_FOOD_METABOLISM_LIVESTOCK.PRODUCT_TYPE] Indicate the product type addressed by the information entered in this record. Leave field empty if not applicable. [Path: TO_FOOD_METABOLISM_LIVESTOCK.PRODUCT_TYPE.LIST_POP] [Path: TO_FOOD_METABOLISM_LIVESTOCK.PRODUCT_TYPE.LIST_POP_TXT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.GUIDELINE] Indicate according to which test guideline the study was conducted. If no test guideline was explicitly followed, but the methodology used is equivalent or similar to a specific guideline, you can indicate so in the "Qualifier" subfield preceding the field "Guideline".Copy this block of fields for specifying more than one guideline (e.g. US EPA in addition to OECD guideline) or for indicating e.g. "no guideline available/required" and "equivalent or similar to" a specific test guideline. [Path: TO_FOOD_METABOLISM_LIVESTOCK.GUIDELINE.QUALIFIER] Select appropriate qualifier, i.e.- "according to" (if a given test guideline was followed);- "equivalent or similar to" (if no test guideline was explicitly followed, but the methodology is equivalent or similar to a specific guideline);- "no guideline followed" (if none of above qualifiers apply. If so, fill in field "Principles of method if other than guideline");- "no guideline available/required" (if applicable; fill in field "Principles of method if other than guideline"). [Path: TO_FOOD_METABOLISM_LIVESTOCK.GUIDELINE.GUIDELINE] Select the applicable test guideline, e.g. "OECD Guideline xxx". If the test guideline used is not listed, choose "other guideline:" and specify the test guideline in the related text field.In this text field, you can also enter any remarks as applicable, particularly:- To include any other title of the test guideline draft used, a subtitle, another version or update number and the year of update (For instance, different titles and/or numbers may exist for a given EU test guideline.);- To indicate if a the study was performed prior to the adoption of the test guideline specified;- To indicate if the methodology used was based on an extension of the test guideline specified. [Path: TO_FOOD_METABOLISM_LIVESTOCK.GUIDELINE.GUIDELINE_TXT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.GUIDELINE.DRAFT] If available, indicate the year the guideline was published / drafted or updated and if necessary, update number. Provide any (sub)title if different from the title given in subfield "Guideline". For instance, different titles and/or numbers may exist for a given EU test guideline. [Path: TO_FOOD_METABOLISM_LIVESTOCK.GUIDELINE.DEVIATION] For robust study summaries or as requested by the regulatory programme, indicate if there are any deviations from the test guideline specified. If "yes" is selected, only briefly state relevant deviations in the supplementary remarks field (e.g. "other species used"); details should be described in the respective fields of the section MATERIALS AND METHODS. [Path: TO_FOOD_METABOLISM_LIVESTOCK.GUIDELINE.DEVIATION_TXT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.METHOD_NOGUIDELINE] If no guideline was followed, include a description of the principles of the test protocol or estimated method used in the study. Details should be entered in appropriate distinct fields of section MATERIALS AND METHODS if available. Also provide a justification for using this method if appropriate.If an estimation method was used (to be indicated in field "Test result type") state the equation(s) and/or computer software or other methods applied to calculate the value(s). [Path: TO_FOOD_METABOLISM_LIVESTOCK.METHOD_NOGUIDELINE.TEXTAREA_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.GLP_COMPLIANCE_STATEMENT] Indicate whether the study was conducted following Good Laboratory Practice or not. Select "yes (incl. certificate)" if a GLP certificate of a test facility is available. Select "yes" if a GLP compliance statement is available, but no information on a GLP certificate. You can give an explanation in the supplementary remarks field, e.g. for explaining why GLP was not complied with or for specifying which (national) GLP was followed. [Path: TO_FOOD_METABOLISM_LIVESTOCK.GLP_COMPLIANCE_STATEMENT.LIST_SEL_FIX] [Path: TO_FOOD_METABOLISM_LIVESTOCK.GLP_COMPLIANCE_STATEMENT.LIST_SEL_FIX_TXT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT_HD] [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT_INDICATOR] Indicate if the test material used in the study is equivalent to the submission substance identity. If "yes" is selected, the corresponding identity is automatically entered in the subsequent block of fields "Test material identity".If "no" is selected, identify the test material in the subsequent block of fields "Test material identity". In this case, also make sure that the information entered in field "Study result type" is consistent, i.e. "read-across from supporting substance (structural analogue or surrogate)".NOTE: If a completed record is used for another submission, you may have to update both fields "Study result type" and "Test material equivalent to submission substance identity". [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT_INDICATOR.LIST_BELOW_SEL] [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT] If the identity of the test material used for this study is not included in this block of fields automatically, indicate the identity for one or more appropriate identifiers, e.g. CAS number, CAS name, IUPAC name. Copy this block of fields as appropriate.If another than the submission substance identity was selected erraneously, go back to field "Test material equivalent to submission substance identity" and select "yes". This will prompt automatic entry of the respective identifiers. [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT.IDENTIFIER] Select an appropriate identifier from drop-down list, e.g. "CAS number". Use "Other:" and specify, if identity according to a standard identifier is not known or if an additional chemical name or number is provided. [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT.IDENTIFIER_TXT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT.ID] Select the corresponding substance identity from drop-down list or enter manually if the identity is not available from the list or if no list is provided for the type of identifier selected. [Path: TO_FOOD_METABOLISM_LIVESTOCK.RADIO_LABEL] Indicate if labelled or non-labelled test material was used. Details on labelled material to be described in field "Details on test material". [Path: TO_FOOD_METABOLISM_LIVESTOCK.RADIO_LABEL.LIST_BELOW_SEL] [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT_DETAILS] Use freetext template and delete/add elements as appropriate. Enter any details that could be relevant for evaluating this study summary or that are requested by the respective regulatory programme. Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) thereof.Note that any information that can be claimed confidential should be included in the subsequent field "Confidential details on test material".Explanations:- Name of test material (as cited in study report): only if different from any other identifiers provided in the preceding fields.- Molecular formula (if other than submission substance): specify- Molecular weight (if other than submission substance): specify- Smiles notation (if other than submission substance): provide if available- InChl (if other than submission substance): provide if available- Structural formula attached as image file (if other than submission substance): see Fig.: only if different from submission substance. Indicate Fig. no. if a file is attached in field "Attached document", e.g. state "see Fig. 1".- Substance type: indicate whether pure active substance, technical product, formulation or other.- Physical state: indicate "gas", "solid" or "liquid" only if different from submission substance or if substance can occur in different physical states.- Analytical purity: specify in %- Impurities (identity and concentrations): specify- Composition of the test material, percentage of components: specify if applicable- Isomers composition: specify if applicable- Purity test date: provide if available- Lot/batch No.: provide if available- Expiration date of the lot/batch: provide if available- Radiochemical purity (if radiolabelling): specify if applicable- Specific activity (if radiolabelling): specify if applicable- Locations of the label (if radiolabelling): specify if applicable- Expiration date of radiochemical substance (if radiolabelling): specify if applicable- Storage condition of test substance: specify if applicable- Stability under test conditions: indicate if available [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT_DETAILS.FREETEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT_CONFIDENTIAL_DETAILS] Enter any confidential information on the test material in this separate field. Use freetext template and delete/add elements as appropriate. Enter any details that could be relevant for evaluating this study summary or that are requested by the respective regulatory programme. Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) thereof.Explanations:- Analytical purity: specify in %- Impurities (identity and concentrations): specify- Composition of the test material, percentage of components: specify if applicable- Purity test date: provide if available- Lot/batch No.: : provide if available- Expiration date of the lot/batch: : provide if available- Isomers composition: specify if applicable [Path: TO_FOOD_METABOLISM_LIVESTOCK.TESTMAT_CONFIDENTIAL_DETAILS.FREETEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.PROPERTIES_TESTMAT_DETAILS] ONLY if the study summary is a read-across to another substance, i.e. analogue or surrogate (e.g. degradation / transformation product), enter any relevant details on the physico-chemical or other relevant properties. Use freetext template and delete/add elements as appropriate.Note that the physico-chemical properties of the substance for which the submission is made should be recorded in the corresponding chapters (templates) and therefore need not be repeated here. Nevertheless, the possible influence of any physico-chemical properties should be indicated / discussed in appropriate fields, particularly in fields "Details on test conditions" and "Details on results". This holds also true if any property of the substance is different in the test medium as compared to the data recorded in the section on physico-chemical properties, e.g. lower water solubility. [Path: TO_FOOD_METABOLISM_LIVESTOCK.PROPERTIES_TESTMAT_DETAILS.FREETEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.ORGANISM_HD] [Path: TO_FOOD_METABOLISM_LIVESTOCK.ORGANISM] Select name of species. If not available from picklist, select "other" and specify. You may copy this field for indicating additional species, if the studies are summarised in one record. However, it may be sensible or required according to legislation-specific guidance to use separate records for each animal species studied. You can include a cross-reference, in field "Same study also described in chapter:", to the record where the methodology is described in detail. [Path: TO_FOOD_METABOLISM_LIVESTOCK.ORGANISM.LIST_POP] [Path: TO_FOOD_METABOLISM_LIVESTOCK.ORGANISM.LIST_POP_TXT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.ORGANISM_DETAILS] Include details on housing conditions and test animals. Use freetext template and delete/add elements as appropriate, or upload predefined table(s), if any, in rich text field "Any other information on materials and methods incl. tables" or adapt table(s) from study report. Use table numbers in the sequence in which you refer to them in the text (e.g. "... see Table 1").The following information should be addressed:HOUSING / HOLDING AREA: Describe the test facilities, i.e. animal housing including size of enclosures, individual vs. group housing, food and water containers, temperature, lighting, and waste handling.TEST ANIMALS: Include information on breed, age, weight, stage of development, health status and condition of test animals. [Path: TO_FOOD_METABOLISM_LIVESTOCK.ORGANISM_DETAILS.FREETEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.DIET_DETAILS] Include details on dietary regime. Use freetext template and delete/add elements as appropriate, upload predefined table(s), if any, in rich text field "Any other information on materials and methods incl. tables" or adapt table(s) from study report. Use table numbers in the sequence in which you refer to them in the text (e.g. "... see Table 1").The following information should be addressed:- Composition of diet: Describe the diet of animals during acclimation and the dosing period regarding: (1) Types of feed (e.g., corn grain, layers mash, alfalfa pellets) and liquids; (2) Quantities provided (i.e., specific amounts or ad libitum).- Feed consumption: Report the feed consumption (dry weight for ruminants) on an individual or treatment group basis throughout the study.- Water: Report water consumption- Acclimation period: specify [Path: TO_FOOD_METABOLISM_LIVESTOCK.DIET_DETAILS.FREETEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.ADMIN_EXP_HD] [Path: TO_FOOD_METABOLISM_LIVESTOCK.ROUTE] Select as appropriate. If not available from picklist, select "other" and specify. [Path: TO_FOOD_METABOLISM_LIVESTOCK.ROUTE.LIST_POP] [Path: TO_FOOD_METABOLISM_LIVESTOCK.ROUTE.LIST_POP_TXT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.DOSING] Include the dosage rates and actual amounts of radiolabeled and unlabeled test material in each dose, depending on the route of administration as mg/kg bw, mg/kg bw/day, mg/kg diet/feed (dry weight basis for ruminants), mg/animal/day or other. Specify the number and timing of doses.As appropriate or if required by the relevant legislation, upload predefined table(s), if any, in rich text field "Any other information on materials and methods incl. tables" or adapt table(s) from study report. Use table numbers in the sequence in which you refer to them in the text (e.g. "... see Table 1"). [Path: TO_FOOD_METABOLISM_LIVESTOCK.DOSING.TEXT_INT] [Path: TO_FOOD_METABOLISM_LIVESTOCK.DOSING_DETAILS] Include further details on the preparation of dose, the rationale for selection of the dose level(s) and analysis of spiked feed samples. Use freetext template (delete/add elements as appropriate) or describe otherwise.The following information should be addressed:PREPARATION OF DOSE: Describe the method of preparation of the dose (mixing with feed or concentrate ration, gelatin capsule, bolus, etc.). Indicate the date of dose preparation and storage conditions prior to its administration.Note: Details on the test material (e.g. simulated or commercial formulation) used should be given in field "Details on test material".RATIONALE FOR SELECTION OF DOSE LEVELS: Briefly describe, i.e. Level of intake expected, Exaggerated levels. Provide justification for other than the recommended dosing scheme.ANALYSIS OF SPIKED FEED: Describe the method used to analyse spiked feeds and the results of such analyses. If the methodology is described in chapter "Analytical methods", you can include a cross-reference to that record in field "Cross-reference to other study".For dermal study:USE OF VEHICLE/ADJUVANS: Indicate whether and what kind of vehicle or adjuvans was used to enhance dermal absorption of the test material into the animal.USE OF RESTRAINERS FOR PREVENTING INGESTION: Indicate whether precautions were taken to assure that dermally applied test material is not orally taken up due to grooming (particularly for ruminant studies). [Path: TO_FOOD_METABOLISM_LIVESTOCK.DOSING_DETAILS.FREETEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.NUMBER_ANIMALS] Report the number of animals per dose group, e.g. per feeding level. [Path: TO_FOOD_METABOLISM_LIVESTOCK.NUMBER_ANIMALS.TEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.STUDY_DESIGN_DETAILS] Include any further relevant details on the study design. [Path: TO_FOOD_METABOLISM_LIVESTOCK.STUDY_DESIGN_DETAILS.TEXTAREA_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.ANALYT_METHOD_DETAILS] Include details on the sampling, handling and preparation of samples and the analytical methodology applied. Use freetext template and delete/add elements as appropriate, or upload predefined table(s), if any, in rich text field "Any other information on materials and methods incl. tables" or adapt table(s) from study report. Use table numbers in the sequence in which you refer to them in the text (e.g. "... see Table 1").The following information should be addressed:IN-LIFE SAMPLING- Milk / eggs collected: Explain the collection of milk and eggs with any deviations from normal practice explained. Note compositing or pooling of samples; no pooling of milk from animals within a dosage group.- Amount of milk and number of eggs produced during normal production: Provide data as indicated.- Urine, faeces, cage wash collected: For feed-through pesticides, include data on urine, feces and cage wash.POST-SLAUGTHER SAMPLING- Mode of sacrifice: Describe- Interval from last dose or treatment to sacrifice: Describe the time interval in hours or days between time of sacrifice and administration of last dose or application of final treatment. Give an explanation of intervals longer than 24 hours and consideration of their effect on residues.- Tissue harvested and their weights: Indicate the tissues taken after sacrifice, their type (e.g., thigh muscle, omental fat, etc.), and their weights.- Specification of and combining of samples from different animals: Indicate if pooling was done (usually acceptable for poultry, but not ruminants).SAMPLE HANDLING AND PREPARATION: Describe the handling of tissues, eggs and milk between sample collection and storage addressing at least following items:- Sample preparation prior to storage: e.g., chopping- Containers- Storage temperature- Length of storage: Include dates of collection, shipping, analysis, etc.- Mode of shipping, if applicable:ANALYTICAL METHODOLOGY- Description of instrumentation, equipment and reagents used for determining total radioactivity in each sample: Give a detailed description of the analytical method employed to measure residues and listing of which chemical species were measured (parent pesticide, metabolites). If the methodology is described in chapter "Analytical methods", you can include a cross-reference to that record in field "Cross-reference to other study".- Extraction schemes: state "see graphic attached" if a figure is attached in field "Attached background material".- Description of extraction and fractionation of radioactivity in each matrix- Chromatographic and spectroscopic behaviour of radioactive residues in extracts of animal matrices, parent, metabolites, and reference standardsRADIOCHEMICAL EXTRACTION EFFICIENCY- Quantitative information on the recovery of the radioactive residue: Report quantitative information on the recovery of the radioactive residue via the extraction methods used, especially as related to (probable) enforcement analytical methods if reported in this report. As appropriate, upload predefined table(s), if any, in rich text field "Any other information on results incl. tables" or adapt table(s) from study report. Use table numbers in the sequence in which you refer to them in the text (e.g. "... see Table 1").Note: Specific tables may be required. Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) thereof. [Path: TO_FOOD_METABOLISM_LIVESTOCK.ANALYT_METHOD_DETAILS.FREETEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.REM_ME_TC] In this field, you can enter any information on materials and methods, for which no distinct field is available, or transfer free text from other databases. You can also open a rich text editor and create formatted text and tables or insert and edit any excerpt from a word processing or spreadsheet document, provided it was converted to the HTML format.Note: One rich text editor field each is provided for the MATERIALS AND METHODS and RESULTS section. In addition the fields "Overall remarks" and "Executive summary" allow rich text entry. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REM_ME_TC.RICHTEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.GEN_RESULTS_HD] [Path: TO_FOOD_METABOLISM_LIVESTOCK.STABILITY_RESULTS] Provide storage stability data showing the behavior of residues as a function of time in tissues, milk, and eggs. Where samples were not analysed within 30 days, provide evidence showing that the storage did not affect the results of the study.As appropriate, upload predefined table(s), if any, in rich text field "Any other information on results incl. tables" or adapt table(s) from study report. Use table numbers in the sequence in which you refer to them in the text (e.g. "... see Table 1").Note: Specific tables may be required. Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) thereof. [Path: TO_FOOD_METABOLISM_LIVESTOCK.STABILITY_RESULTS.TEXTAREA_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.RADIOACTIVE_RESIDUES] Report amount of radioactivity in each sample fraction, quantified in terms of total radioactive counts and as both percentage and concentration (mg/kg, as parent equivalents) in the original sample matrix analysed.As appropriate, upload predefined table(s), if any, in rich text field "Any other information on results incl. tables" or adapt table(s) from study report. Use table numbers in the sequence in which you refer to them in the text (e.g. "... see Table 1").Note: Specific tables may be required. Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) thereof. [Path: TO_FOOD_METABOLISM_LIVESTOCK.RADIOACTIVE_RESIDUES.TEXTAREA_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.RESIDUES_DISTRIBUTION] Report quantitative information on the recovery of the radioactive residue from the animal tissues, milk, and eggs via the extraction methods used, especially as related to (probable) enforcement analytical methods.As appropriate, upload predefined table(s), if any, in rich text field "Any other information on results incl. tables" or adapt table(s) from study report. Use table numbers in the sequence in which you refer to them in the text (e.g. "... see Table 1").Note: Specific tables may be required. Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) thereof. [Path: TO_FOOD_METABOLISM_LIVESTOCK.RESIDUES_DISTRIBUTION.TEXTAREA_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.RESIDUES_CHARACTERISATION] Describe the characterisation and/or identification of radioactive residues, data for all major components, whether free, conjugated, non-extractable, or natural constituent, to reflect their presence within the tissue, eggs, or milk expressed as both percentage of the TRR and concentration (in mg/kg). As appropriate, upload predefined table(s), if any, in rich text field "Any other information on results incl. tables" or adapt table(s) from study report. Use table numbers in the sequence in which you refer to them in the text (e.g. "... see Table 1").Note: Specific tables may be required. Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) thereof. [Path: TO_FOOD_METABOLISM_LIVESTOCK.RESIDUES_CHARACTERISATION.TEXTAREA_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.PATHWAY_METABOLIC] Discuss the routes of degradation or metabolism observed in the animal and describe the metabolic pathways and/or attach figures in field "Attached background material".If the relevant legislation requires to include a comparison to other studies in this study summary, discuss the metabolism/degradation observed in other livestock studies, in rats, and in plant metabolism studies (if available at the time of conduct of this study). Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) whether such comparative appraisal should rather be included in a summary record. [Path: TO_FOOD_METABOLISM_LIVESTOCK.PATHWAY_METABOLIC.TEXTAREA_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.REM_RS] In this field, you can enter any other information on results, for which no distinct field is available, or transfer free text from other databases. You can also open a rich text editor and create formatted text and tables or insert and edit any excerpt from a word processing or spreadsheet document, provided it was converted to the HTML format.Note: One rich text editor field each is provided for the MATERIALS AND METHODS and RESULTS section. In addition the fields "Overall remarks" and "Executive summary" allow rich text entry. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REM_RS.RICHTEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.GEN_OVERALL_HD] [Path: TO_FOOD_METABOLISM_LIVESTOCK.REM_ANYOTHER] In this field, you can enter any overall remarks or transfer free text from other databases. You can also open a rich text editor and create formatted text and tables or insert and edit any excerpt from a word processing or spreadsheet document, provided it was converted to the HTML format.Note: One rich text editor field each is provided for the MATERIALS AND METHODS and RESULTS section. In addition the fields "Overall remarks" and "Executive summary" allow rich text entry. [Path: TO_FOOD_METABOLISM_LIVESTOCK.REM_ANYOTHER.RICHTEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.AD] Attach any background document that cannot be inserted in any rich text editor field, particularly image files (e.g. an image of a structural formula).Copy this block of fields for attaching more than one file. [Path: TO_FOOD_METABOLISM_LIVESTOCK.AD.DOC] Upload file by clicking the upload icon. As appropriate, enter any additional information, e.g. language. The file name is displayed after uploading the document. [Path: TO_FOOD_METABOLISM_LIVESTOCK.AD.REM] As appropriate, include remarks, e.g. a short description of the content of the attached document if the file name is not self-explanatory. [Path: TO_FOOD_METABOLISM_LIVESTOCK.AD_STUDYREPORT] If required, an electronic copy of the full study report can be attached as WORD, pdf or other document type, which will not be integrated in any report, but must be handled as separate files.Note: In the export administration you can indicate whether the attached files should be included in the data export or not. [Path: TO_FOOD_METABOLISM_LIVESTOCK.AD_STUDYREPORT.ATTACHMENT_BELOW] Upload file by clicking the upload icon. As appropriate, enter any additional information, e.g. language. The file name is displayed after uploading the document. [Path: TO_FOOD_METABOLISM_LIVESTOCK.GEN_APPL_SUM_HD] [Path: TO_FOOD_METABOLISM_LIVESTOCK.APPL_CL] Enter any conclusions if applicable. [Path: TO_FOOD_METABOLISM_LIVESTOCK.APPL_CL.TEXTAREA_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.APPL_EXEC_SUM] If required by the respective national/regional programme, briefly summarise the relevant aspects of the study including the conclusions reached. If a specific format is prescribed, upload the respective freetext template if available from the drop-down list or copy it from the corresponding document.Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) thereof. [Path: TO_FOOD_METABOLISM_LIVESTOCK.APPL_EXEC_SUM.RICHTEXT_BELOW] [Path: TO_FOOD_METABOLISM_LIVESTOCK.CROSSREF_OTHER_STUDY] A Cross-reference to other study or other studies can be included which are considered relevant in the interpretation of the test results, e.g. for supporting the conclusion that an effect observed was not substance-related. Indicate the respective chapter(s) and record ID(s) and enter relevant explanatory text.Such cross-references may be useful if it is considered relevant to discuss other results at the summary level of a single study. It should be noted that the overall appraisal of results from different studies is normally done in the hazard or risk assessment.Note that any such cross-reference may become useless if a record is either printed or exchanged on its own. [Path: TO_FOOD_METABOLISM_LIVESTOCK.CROSSREF_OTHER_STUDY.TEXT_BELOW] The version timestamp associates the XSDs with the underlying data format specification version as published by the IUCLID Management Group. See also layout.xml and the version attribute in data documents. The document reference pointing to the current document robust study flag used for classification flag used for MSDS flag