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OECD's current priority is to develop new and revised Test Guidelines to detect endocrine disrupters. This is to address the concern of its Member countries that currently no existing Test Guidelines are fully sufficient to identify the potential effects of endocrine disrupting substances. This issue was given very high priority for Test Guideline Development by the Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology.
The work includes the development of test guidelines for both human health and the environment, and is guided by a conceptual framework. The tests listed in the conceptual framework constitute many tools which can be used independently of each other and do not each represent data requirements.
The projects being addressed by OECD include the following:
Mammalian work
- Peer-review of the rodent uterotrophic assay to detect oestrogenic effects
- Validation of the rodent Hershberger assay to detect androgenic effects
- Consideration of enhancements to the existing OECD TG 407 (Repeated Dose Oral Toxicity)
- Further enhancement of TG 416 (Two-generation reproduction test)
Ecotoxicological Work
- Development and validation of a fish 21-day assay (Phase 1A and Phase 1B completed)
- Development and validation of a fish development test
- Validation of a fish FLC test or a fish 2-Gen test
- (One) and/or two generation avian reproductive test in birds (quail)
- Development and validation of the Amphibian Metamorphosis Assay
- Development and validation of the Copepod Development and Repro. test
Useful links to relevant endocrine disrupter national and regional programmes
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