Manual for Investigation of HPV Chemicals
ANNEX 1: OECD Test Guidelines for Studies Included in the SIDS
All related Test Guidelines can be downloaded from this page.
This document provides access to OECD Test Guidelines for SIDS elements.
Figures in [ ] correspond to the data elements in the SIDS Dossier (see Chapter 2, Annex 1: Guidance for completing a SIDS Dossier).
2. PHYSICAL-CHEMICAL DATA
[2.1] MELTING POINT Ref. OECD TG 102 ( PDF)
[2.2] BOILING POINT Ref. OECD TG 103 ( PDF)
[2.3] DEPDFNSITY Ref. OECD TG 109 ( PDF)
[2.4] VAPOUR PRESSURE Ref. OECD TG 104 ( PDF)
[2.5] PARTITION COEFFICIENT N-OCTANOL/WATER Ref. OECD TG 107 ( PDF) and TG 117 ( PDF)
[2.6.1.] WATER SOLUBILITY Ref. OECD TG 105 ( PDF) as well as pH VALUE AND pKA VALUE: Ref. OECD TG 112 ( PDF)
3. ENVIRONMENTAL FATE AND PATHWAYS
[3.1.B] STABILITY IN WATER (HYDROLYSIS) Ref. OECD TG 111 ( PDF)
[3.4] AEROBIC BIODEGRADATION
- Ready Biodegradability; Ref. OECD TG 301A-F ( PDF)
- Inherent Biodegradability; Ref. OECD TG 302A ( PDF), 302B ( PDF), 302C ( PDF)
4. ECOTOXICITY
[4.1] ACUTE/PROLONGED TOXICITY TO FISH
- Fish, Acute Toxicity Test; Ref. OECD TG 203 ( PDF)
[4.2] ACUTE TOXICITY TO AQUATIC INVERTEBRATES
- Daphnia sp.: Acute Immobilisation Test; Ref. OECD TG 202, part I ( PDF)
[4.3] TOXICITY TO AQUATIC PLANTS e.g. ALGAE
- Alga, Growth Inhibition Test; Ref. OECD TG 201 ( PDF)
[4.5] CHRONIC TOXICITY TO AQUATIC ORGANISM
[4.5.A] CHRONIC TOXICITY TO FISH
- Fish, Early Life Stage Toxicity Test; Ref. OECD TG 210 ( PDF)
[4.5.B] CHRONIC TOXICITY TO AQUATIC INVERTEBRATES
- Daphnia magna Reproduction Test; Ref. OECD TG 211 ( PDF)
[4.6] TOXICITY TO TERRESTRIAL ORGANISM
[4.6.A] TOXICITY TO TERRESTRIAL PLANTS Ref. OECD TG 208 ( PDF)
[4.6.B] TOXICITY TO SOIL DWELLING ORGANISM
- Earthworm Acute Toxicity Tests; Ref. OECD TG 207 ( PDF)
[4.6.C] TOXICITY TO OTHER NON-MAMMALIAN TERRESTRIAL SPECIES (INCLUDING AVIANS)
- Avian Dietary Toxicity Test; Ref. OECD TG 205 ( PDF)
- Avian Reproduction Test; Ref. OECD TG 206 ( PDF)
- Soil Microorganisms: Nitrogen Transformation Test; Ref OECD TG 216 ( PDF)
- Soil Microorganisms: Carbon Transformation Test; Ref OECD TG 217 ( PDF)
5. TOXICITY
[5.2] ACUTE TOXICITY Ref. OECD TG 402 ( PDF), 403 ( PDF), 420 ( PDF), 423 ( PDF)and 425 ( PDF)
[5.5] REPEATED DOSE STUDY (14- 28 DAY) Ref. OECD TG 407 ( PDF), 410 ( PDF), 412 ( PDF)
- Note: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD Test Guideline 422 ( PDF)) is acceptable.
[5.6] GENETIC TOXICITY (in vitro)
[5.6.A.] GENETIC TOXICITY in vitro (GENE MUTATION)
- Bacterial Reverse Mutuation Test; Ref. OECD TG 471 ( PDF)
- In vitro Mammalian Cell Gene Mutation Test; Ref. OECD TG 476 ( PDF)
[5.6.B.] GENETIC TOXICITY in vitro (CHROMOSOMAL ABERRATION)
- In vitro Mammalian Chromosomal Aberration Test; Ref. OECD TG 473 ( PDF)
[5.7] GENETIC TOXICITY in vivo
- Mammalian Erythrocyte Micronucleus Test; Ref. OECD TG 474 ( PDF)
- Mammalian Bone Marrow Chromosomal Aberration Test; Ref. OECD TG 475 ( PDF)
[5.9] REPRODUCTIVE TOXICITY (including Fertility and Developmental Toxicity)
[5.9.A] FERTILITY
- One Generation Reproductions Toxicity Study; Ref. OECD TG 415 ( PDF)
- Two Generation Reproduction Toxicity Study; Ref. OECD TG 416 ( PDF)
- Note: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD Test Guideline 422 ( PDF)) and Reproduction/Developmental Toxicity Screening Test (OECD Test Guideline 421 ( PDF)) are also acceptable.
[5.9.B] DEVELOPMENTAL TOXICITY
- Pre-natal Developmental Toxicity Study; Ref. OECD TG 414 ( PDF)
- Note: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD Test Guideline 422 ( PDF)) and Reproduction/Developmental Toxicity Screening Test (OECD Test Guideline 421 ( PDF)) are also acceptable.
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