| DRAFT DOCUMENTS IN A COMMENTING ROUND |
Instructions for Commenting on Draft Guidance and Review Documents
Template for submission of comments (optional)
GD Endocrine Disruption: Guidelines for Histological Evaluation
Part 1: Guidelines for dissection and trimming of endocrine tissues
Part 2: Male reproductive system [PDF1] [PDF2] [PDF3] [PDF4] [PDF5] [PDF6] [PDF7]
Part 3: Female reproductive system (parts 3a, 3b and 3c can be grouped under this title) [PDF3a] [PDF3b] [PDF3c]
Part 4: Mammary gland [PDF1] [PDF2] [PDF3] [PDF4] [PDF5]
Part 5: Preparation, reading and reporting of vaginal smears
Part 6: Pituitary gland
Deadline for public comments: 20 June 2008
RPA Draft Retrospective Perfomance Assessment of the TG 426 on Developmental Neurotoxicity PDF
Deadline for public comments: 18 February 2008
GD N.43 Draft Guidance Document on Mammalian Reproductive Toxicity Testing and Assessment PDF
Deadline for public comments: 12 February 2008
GD The Draft Guidance for a Single Dose Study for the Derivation of an Acute Reference Dose PDF
Deadline for public comments: 15 January 2008
DRP The Use of Metabolising Systems for In Vitro Testing of Endocrine Disrupters - A Detailed Review Paper PDF (Document replaced on 29 August due to an error in the original source used in Figure 4).
Deadline for public comments: 10 September 2007
| DRAFT DOCUMENTS FOR WHICH COMMENTING PERIOD HAS EXPIRED AND WHICH ARE BEING REVISED OR FINALISED |
Draft Revised Version of the DRP No.31 on Cell Transformation Assays for Detection of Chemical Carcinogens (December 2006) PDF
DRP Draft Detailed Review Paper on Avian 2-Generation Toxicity (version June 2006) PDF
2nd version - deadline for public comments passed: 27 August 2006
1st version - deadline for public comments passed: 1st September 2003
DRP Draft Detailed Review paper on the Use of Metabolising Systems for in vitro Testing of Endocrine Disrupters (version March 2006) PDF
Deadline for public comments passed: 28 April 2006
GD Draft Guidance Document on Honey Bee (Apis Mellifera L.) Brood Test Under Semi-Field Conditions (February 2006 version) PDF
Deadline for public comments passed: 24 March 2006
DRP Draft Detailed Review paper on Cell Transformation Assays for Detection of Chemical Carcinigens (3rd version, February 2006) PDF
Deadline for public comments passed: 29 March 2006
DRP Draft Detailed Review Paper on Thyroid Hormone Disrupting Assays (March 2005 version) PDF
Deadline for public comments passed: 20 May 2005
DRP Draft Detailed Review Paper on Transgenic Rodent Mutation Assays (February 2005 version) PDF (3.5MB)
Deadline for public comments passed: 29 April 2005
For your convenience the document has been divided into separate chapters:
Table of Contents
Executive Summary
Chapter 1 - Description of Transgenic Rodent Models and Overview of the Transgenic Rodent Mutation Experiment
Chapter 2 - Existing Genotoxicity Assays
Chapter 3 - Transgenic Rodent Mutation Assays: Existing Data and Current Level of Understanding of Factors Influencing Performance
Chapter 4 - Predictive Ability of Transgenic Rodent Mutation Assays
Chapter 5 - Recommendations for the conduct of Transgenic Rodent Mutation Assays
Appendix 1 - Experimental Data sorted by Chemical
Appendix 2 - Genotoxicity and Carcinogenicity Data sorted by Chemical
Appendix 3 - TGR Mutagenicity Data of Carcinogens in Target Tissues
References
Deadline for public comments passed: 1st December 2003
DRP Draft Detailed Review Paper on Aquatic Arthropods (January 2005 version) PDF
Deadline for public comments passed: 18 February 2005
DRP No. 31 Detailed Review Paper on Non-genotoxic carcinogens detection: the Performance of in-vitro cell transformation assays (May 2001 version) PDF
Deadline for public comments passed: 1st October 2001
GD No. 39 Draft Guidance Document on Acute Inhalation Toxicity (October 2002 version) PDF and Draft New Test Guideline 433 on Acute Inhalation Toxicity
Deadline for public comments passed: 20 January 2003
GD No. 39B Draft Guidance Document on Acute Inhalation Toxicity Testing (December 2004 version) PDF
Deadline for public comments passed: 28 January 2005
GD No. 43 Draft Guidance Document on Reproductive Toxicity Testing and Assessment (November 2004 version) PDF
Deadline for public comments passed: 28 January 2005
DRP Draft Detailed Review Paper on Steroidogenesis (split in 2 due to large file size) PDF1 PDF2
Deadline for public comments passed: 1st August 2003
DRP Draft Detailed Review Paper on Aromatase PDF
Deadline for public comments passed: 1st August 2003
GD Draft Guidance Document on the Statistical Analysis of Ecotoxicity Data (May 2003 version) PDF
Deadline for public comments passed: 1st August 2003
DRP Draft Detailed Review Paper on Fish Two-Generation (March 2003 version) PDF and Proposal for a Fish Two-Generation Test Guideline (March 2003 version) PDF
Deadline for public comments passed: 24th April 2003
GD Draft Guidance Document on Testing Avian Avoidance Behaviour (Pen Test)
Deadline for public comments passed: 15th May 2003
GD Freshwater Lentic Field Studies (July 2004 version) PDF
Compilation of Comments PDF
Deadline for public comments passed: 8th September 2004
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