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Testing of chemicals

Performance Standards

 

Performance standards are based on an adequately validated test method and provide a basis for evaluating the comparability of a proposed test method that is mechanistically and functionally similar.

Read this first: As indicated in the Performance Standards documents below, similar methods to the Validated Reference Method(s) should not be developed on the basis of a majority of reference substances, but rather on a larger set of tested chemicals. Reference substances should be preferentially used to determine equivalence of performance compared to the validated reference test methods.

The three elements of performance standards are:

  1. Essential test method components, 
  2. List of reference substances; and  
  3. Accuracy and reliability performance values.

No. 222 Performance Standards for the Human Recombinant Estrogen Receptor Binding Assay

No. 220 Performance Standards for the Assessment of Proposed Similar or Modified In Vitro Reconstructed Human Epidermis (RhE) Test Methods for Skin Irritation Testing as described in TG 439

No. 219 Performance Standards for the Assessment of Proposed Similar or Modified In Vitro Reconstructed Human Epidermis (RHE) Test Methods for Skin Corrosion Testing as described in TG 431

No. 218 Performance Standards for the Assessment of Proposed Similar or Modified In Vitro Reconstructed Human Epidermis (RHE) Test Methods for Skin Corrosion Testing as described in TG 430

No. 216 Performance Standards for the Assessment of proposed Similar or Modified In Vitro Reconstructed Human Cornea-like Epithelium (RHCE) Test Methods for Eye Hazard

No. 213: Performance Standards for Assessment of Proposed Similar or Modified In Vitro Skin Sensitisation ARE-NRF2 Luciferase Test Methods 

No. 174: Second Edition Performance Standards For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Antagonists

No. 173: Performance Standards for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Agonists for TG 455

Further Reading

 

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