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  • 28-February-2019

    English

    Saving Costs in Chemicals Management - How the OECD Ensures Benefits to Society

    The chemical industry is one of the largest industrial sectors in the world and is expected to grow fourfold by 2060. Indeed modern life without chemicals would be inconceivable. Given the potential environmental and human health risks from exposure to chemicals, governments and industry have a major responsibility to ensure that chemicals are produced and used safely.

    The OECD assists countries in developing and implementing policies and instruments that protect human health and the environment, and in making their systems for managing chemicals as efficient as possible. To eliminate duplication of work and avoid non-tariff barriers to trade, emphasis has been on developing shared frameworks for gathering and assessing information on potential chemical risks. The time-tested OECD Mutual Acceptance of Data (MAD) system provides a major basis for generating savings to governments and industry. This report provides an overview of the benefits and estimates the total savings from OECD work to be more than EUR 309 million per year.
  • 11-February-2019

    English

    Webinar Series on Emerging Science to Improve Chemical Safety

    Join us on 11 February 2019 to learn and discuss new methodologies developed by research globally. These new approaches might make their way into future regulatory applications, but a dialogue will help scientists understand the needs of the regulatory community, and allow regulators to ask the relevant questions early on.

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  • 8-February-2019

    English

    Draft Guidance and Review Documents/Monographs

    Deadlines for comments: 8 February 2019 for the draft Performance Standards for the Validation and Assessment of Similar Test Method; and 31 January 2019 for the draft Guiding Principles for Good Licensing Practices for protected Elements in OECD Test Guidelines.

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  • 22-January-2019

    English

    Draft documents for public comments

    This page contains a list of the Guidelines for the Testing of Chemicals.

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  • 18-January-2019

    English

    Webinar Series on Testing and Assessment Methodologies

    On 16 January 2019, Patience Browne of the Environment Directorate presented an overview of an on-going project led by the European Commission Joint Research Centre/the United States/ Health Canada.

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  • 15-January-2019

    English

    Section 4: Health Effects

    Consult the January and February 2019 deadlines for comment of various OECD Guidelines for the Testing of Chemicals: in Vitro 3T3 NRU phototoxicity test; Vitrigel Eye Irritancy Test Method; in vitro Macromolecular Test Method for Eye Hazard Potential; and In Chemico Skin Sensitisation Assays addressing the AOP Key Event of covalent binding to proteins.

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  • 11-December-2018

    English

    Series on Testing and Assessment: publications by number

    The aim of this document is to provide guidance in order to reduce the uncertainties in cell and tissue-based in vitro method derived predictions by applying all necessary good scientific, technical and quality practices from method development to implementation for regulatory use.

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  • 10-December-2018

    English

    Series on Testing and Assessment: Testing for Endocrine Disrupters

    The series on endocrine disrupters provides common tools and guidances for testing the effects of endocrine disrupting chemicals on the oestrogen, androgen and thyroid hormone systems. Using these validated methodologies, regulatory authorities can use internationally harmonised tools to evaluate chemicals of concern for human health and/or the environment as well as testing costs.

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  • 24-October-2018

    English

    Adverse Outcome Pathways, Molecular Screening and Toxicogenomics

    The first report describes the linkage between inhibition of complex I of the mitochondrial respiratory chain and motor deficit as in parkinsonian disorders. The second report links chronic binding of antagonist to N-methyl-D-aspartate receptors during brain development leading to neurodegeneration. The third report details the linkage between binding and activation of androgen receptor leading to reproductive dysfunction.

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  • 22-October-2018

    English

    OECD Test Guidelines for the Chemicals

    The OECD Guidelines are a unique tool for assessing the potential effects of chemicals on human health and the environment. Accepted internationally as standard methods for safety testing, the Guidelines are used by professionals in industry, academia and government involved in the testing and assessment of chemicals. These Guidelines are regularly updated with the assistance of thousands of national experts from OECD member countries.

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