Join us on 30 April 2019 to learn and discuss the Adverse Outcome Pathway (AOP) framework. The AOP framework is a collaborative tool that applies an innovative approach for collecting mechanistic knowledge from various sources that can eventually support chemical safety assessment.
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This new edition of the OECD work on Chemical Safety and Biosafety highlights the activities, results and ongoing projects as outlined by the 2019-2020 work programme.
On 11 February 2019, the OECD organised a webinar to learn and discuss new methodologies on liver models for induction, clearance and toxicity. The speakers presented the benefits compared to existing methods in place, the types of chemicals tested, the results obtained, the transferability and economic aspects for routine testing, and any known limitation to the technologies and their applications.
Deadlines for comments: 8 February 2019 for the draft Performance Standards for the Validation and Assessment of Similar Test Method; and 31 January 2019 for the draft Guiding Principles for Good Licensing Practices for protected Elements in OECD Test Guidelines.
The OECD has published the Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.
The OECD has developed the Mutual Acceptance of Data (MAD), a multilateral agreement which allows participating countries (including non members) to share the results of various non-clinical tests done on chemicals using OECD methods and principles. MAD reduces duplicative testing, allows governments to work together when assessing chemicals, and saves government and industry resources.
The first report is a synthesis from a Workshop on Approaches to Support Substitution and Alternatives Assessment, which discussed approaches used to support alternative assessments and substitution. The second report is a Cross Country Analysis of Approaches to Support Alternatives Assessment and Substitution of Chemicals of Concern that describes a list of approaches developed across countries and by different stakeholders.
The OECD Guidelines are a unique tool for assessing the potential effects of chemicals on human health and the environment. Accepted internationally as standard methods for safety testing, the Guidelines are used by professionals in industry, academia and government involved in the testing and assessment of chemicals. These Guidelines are regularly updated with the assistance of thousands of national experts from OECD member countries.
The first report describes the linkage between inhibition of complex I of the mitochondrial respiratory chain and motor deficit as in parkinsonian disorders. The second report links chronic binding of antagonist to N-methyl-D-aspartate receptors during brain development leading to neurodegeneration. The third report details the linkage between binding and activation of androgen receptor leading to reproductive dysfunction.