Testing of chemicals


  • Webinar on emerging science to improve chemical safety: liver models for induction, clearance and toxicity

    11 February 2019: Join us to learn and discuss new methodologies on liver models for induction, clearance and toxicity. The speakers will present the benefits compared to existing methods in place, the types of chemicals tested, the results obtained, the transferability and economic aspects for routine testing, and any known limitation to the technologies and their applications.

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  • Guidance Document on Good In Vitro Method Practices (GIVIMP)

    This document provides detailed guidance on good scientific, technical and quality practices to assure the reliability of data derived from cell and tissue based in vitro toxicity test methods. It primarily targets practitioners working in the development and application of in vitro methods and associated Test Guidelines intended for the regulatory safety assessment of chemicals used in different sectors. The project to develop the guidance has been led by the European Commission’s Joint Research Centre (JRC).

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  • Three new publications on Adverse Outcome Pathways

    The first publication describes the linkage between inhibition of complex I of the mitochondrial respiratory chain and motor deficit as in parkinsonian disorders. The second publication links chronic binding of antagonist to N-methyl-D-aspartate receptors during brain development leading to neurodegeneration. The third publication details the linkage between binding and activation of androgen receptor leading to reproductive dysfunction.

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OECD assists countries in harmonising Guidelines for the Testing of Chemicals and Good Laboratory Practice, in order to ensure high quality and reliable data and for countries and industry to fully benefit from the OECD agreement on Mutual Acceptance of Data (MAD) and avoid duplicative testing.


What is the Mutual Acceptance of Data (MAD)?

The MAD system helps to avoid conflicting or duplicative national requirements, provides a common basis for co-operation among national authorities and avoids creating non-tariff barriers to trade. OECD countries and full adherents have agreed that a safety test carried out in accordance with the OECD Test Guidelines and Principles of Good Laboratory Practice in one OECD country must be accepted by other OECD countries for assessment purposes. This is the concept of “tested once, accepted for assessment everywhere*”. This saves the chemicals industry the expense of duplicate testing for products which are marketed in more than one country. 

*While the receiving government must accept the study, how it interprets study results is its own prerogative. 


Did you know?

By reducing duplication, and creating a framework for the sharing of work, the MAD system saves governments and industry around €150,000,000 each year, as well as reduces the number of animals used in such testing.


Key areas of work

> OECD Guidelines for the Testing of Chemicals 

> Good Laboratory Practice


Cutting Costs in Chemicals Management

 Cutting costs in chemicals management


Guidance Document on evaluating Chemicals for Endocrine Disruption

 This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.


Guidance Document on Good In Vitro Method Practices (GIVIMP)


 Guidance Document on Good In Vitro Methods Practices (GIVIMP)