Chemical safety and biosafety

Section 4: Health Effects

 

important notice

The draft Test Guidelines are not part of Mutual Acceptance of Data (MAD); consult with national authorities before using the draft Test Guidelines.

NEW DEADLINE for comments 

Deadline for comments: 7 December 2018

Draft Updated Test Guideline 488 on Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

DEADLINE FOR COMMENTS: 16 NOVEMBER 2018

DRAFT GUIDELINE ON DEFINED APPROACHES FOR SKIN SENSITISATION

SUPPORTING DOCUMENT FOR THE GL FOR DAS FOR SKIN SENSITISATION

Deadline for comments: 9 November 2018

Revised draft Test Guideline on an In vitro Macromolecular Test Method for i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

Revised draft Performance Standards for the Validation and Assessment of Similar Test Method

Deadline for comments: 5 November 2018

Draft updated TG 442C: In Chemico Skin Sensitisation Assays addressing the AOP Key Event of covalent binding to proteins

Deadline for comments: 2 November 2018

Draft Updated Test Guideline 439 on In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method

Deadline for comments: 5 October 2018

Draft TG 432: In Vitro 3T3 NRU phototoxicity test

Deadline for comments: 5 October 2018

Draft Proposal for a new TG: ROS (Reactive Oxygen Species) Assay for Photoreactivity

Deadline for comments: 28 September 2018

Draft proposal for a new TG:  Vitrigel-Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage and draft Performance Standards (PS)

 

 

RECENT DRAFT GUIDELINES

Draft Proposal for a New Performance Based TG - Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method (PDF)

Draft Performance Standards for New Human Cytochrome P450 (CYP) n-fold Induction in vitro Test Method  (PDF)
Multi-study Validation Trial for Cytochrome P450 Induction Providing a Reliable Human Metabolically Competent Standard Model or Method Using the Human Cryopreserved Primary Hepatocytes and the Human Cryopreserved HepaRG® Cell Line (PDF)
Deadline for public comments*: 21 October 2014

 

further reading

* Comments should be sent to the Secretariat by National Coordinators by the indicated date. Anyone who would like to contribute to a commenting round is invited to contact their National Coordinator beforehand to discuss together of a timeframe for comment submission.

In Vitro3T3 NRU phototoxicity test

 

 

Related Documents

 

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