30/01/2013 – Recently the OECD release the third generation of the QSAR Toolbox. The existing tutorials and videos have now been updated according to the new version of the QSAR Toolbox to help the user building categories that are mechanistically and structurally robust to maximise success in filling data gaps for the endpoint of interest. Mid next year the OECD is planning to release additional training material.
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The Toolbox 3.1 installation is a minor update distributed as a standalone installation as well as a patch to Toolbox 3.0. When applying patch, upon first start of the application, an update procedure will be performed on the database. It is a onetime operation that should not be canceled.
US Environmental Protection Agency derived the Human health benchmarks for pesticides by applying the health effects data from pesticide registrations to the typical methods used for developing drinking water health advisories. It was developed to enable states, water systems and the public to better determine whether the detection of a pesticide in drinking water or source waters for drinking water may indicate a potential health risk.
The OECD Environmental Risk Assessment Toolkit describes the work flow for environmental risk assessment and management of chemicals with links to available OECD material relevant for the different steps in risk assessment and management. This new version of the Toolkit is more interactive and has added functionalities. It will be populated with additional tools and case studies in the future.
The aquatic life benchmarks (for freshwater species) are based on toxicity values reviewed by EPA and used in the Agency's most recent risk assessments developed as part of the decision-making process for pesticide registration. Each Aquatic Life Benchmark is based on the most sensitive, scientifically acceptable toxicity endpoint available for a given taxon of all scientifically acceptable toxicity data available to EPA.
This document provides detailed guidance for both new chemical notifiers and jurisdictions who wish to participate in a “parallel process” which enables a company to declare to all affected countries at the time of first notification that it wants them to cooperate and share information. The hazard assessment is developed by the ‘lead’ jurisdiction and then utilized by other participating jurisdictions.
An adverse outcome pathway can be incorporated into chemical categories-based assessments or integrated approaches for testing and assessment.
This document describes the state of knowledge of the adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence for the AOP, identifies the key events, and identifies databases containing test results related to those key event
This OECD Emission Scenario Document (ESD) is intended to provide information on the sources, use patterns and release pathways of chemicals used in oil well production to assist in the estimation of releases of chemicals to the envi
This document outlines a crosswalk between the function and product categorization of chemicals used by the United States and Canada with the function, product and article categories used in the European Union in the context of the implementation of the REACH regulation.