This document outlines the methodologies and tools currently used to assess the risk of chemicals to children’s health and also identifies possible needs for additional guidance or tools based on the results of an on-line survey conducted in November 2011. The following areas of risk assessment are covered: definitions, hazard and exposure assessment, risk characterisation, cohort studies and combined exposure to multiple chemicals.
The Gefahrstoffdatenbank der Länder, a german database, is now linked to eChemPortal. 102545 substance records can be searched through the substance search. This includes German hazardous substances legislation as well as other sources reflecting the state of technology and occupational health and safety relating to activities involving hazardous substances. In addition, it contains links to various other German data bases.
Four new tutorials are available that provide illustrated examples for the use of the functionalities of the Query tool , the AOP workflow for Skin Sensitization, the information form the ECHA CHEM database and the capability to analyse tautomeric structures. The examples cover both human health (skin sensitisation) and environmental (acute aquatic toxicity to fish) endpoints.
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11/07/2013 –Recently the OECD released the third generation of the QSAR Toolbox. For this purpose, the guidance document for grouping chemicals to fill data gaps for acute aquatic toxicity have been updated. This guidance document should support the user of the QSAR Toolbox to build categories that are mechanistically and structurally robust.
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11/07/2013 –Recently the OECD released the third generation of the QSAR Toolbox. For this purpose, the guidance document for grouping chemicals to fill data gaps for genetic toxicity and genotoxic carcinogenicity have been updated. This guidance document should support the user of the QSAR Toolbox to build categories that are mechanistically and structurally robust.
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Global Portal to Information on Chemical Substances, is to be the preferred worldwide source of information about chemicals from authorities and international organisations.
This guidance document intends to provide an insight into which pieces of information that are necessary to identify and document an adverse outcome pathway (AOP) and how to present them. The AOP concept has been developed as a means of providing transparent mechanistic justification and weight-of-evidence to reduce uncertainty in the predictions for complex toxicological endpoints.
This document provides guidance for performing an exposure assessment based on environmental monitoring data.It covers topics such as environmental levels and distribution of contaminants, ways of using monitoring data in exposure assessments for differing purposes, the collection of data, quality of monitoring activities, as well as several examples of data compilation in member countries and their use in exposure assessment.
30/01/2013 –The first update to the third generation of the QSAR Toolbox (version 3.1) has now been released containing improved search functionalities, interface improvement, a new database for observed rat in vivo metabolism; updated auto oxidation and metabolism simulators; updated DNA binding profiler and additional ways of expressing mixtures composition.
30/01/2013 – Recently the OECD release the third generation of the QSAR Toolbox. The existing tutorials and videos have now been updated according to the new version of the QSAR Toolbox to help the user building categories that are mechanistically and structurally robust to maximise success in filling data gaps for the endpoint of interest. Mid next year the OECD is planning to release additional training material.