Chemical safety and biosafety

OECD Guidelines for the Testing of Chemicals

 

What's new

On 25 June, OECD adopted a set of new and updated Test Guidelines for chemicals safety testing.

Those include two new Test Guidelines on in vitro methods for fish hepatic clearance, TG 319A and TG 319B that can be used to improve in silico predictions of the test chemical bioaccumulation in fish.

Important updates to existing Test Guidelines encompass the inclusion of endocrine-related endpoints in TG 408 (90-d repeated dose toxicity study) and TG 414 (Developmental toxicity study); also Test Guidelines in the area of eye irritation and skin sensitisation have been revised to either improve predictivity of the existing method (TG 438, isolated chicken eye method) or include similar methods to those already existing (me-too methods in TG 442B, TG 442D, TG 492) ensuring more readily usable practical matter by members and Mutual Acceptance of Data (MAD) adhering countries.

A few other Test Guidelines have been slightly amended as well and can be accessed from the sections mentioned below:

A set of supporting documents and Guidance Documents associated to these Test Guidelines will soon be published, stay tuned!

 

The OECD Test Guidelines Programme

The OECD Guidelines are a unique tool for assessing the potential effects of chemicals on human health and the environment. Accepted internationally as standard methods for safety testing, the Guidelines are used by professionals in industry, academia and government involved in the testing and assessment of chemicals (industrial chemicals, pesticides, personal care products, etc.). These Guidelines are regularly updated with the assistance of thousands of national experts from OECD member countries. OECD Test Guidelines are covered by the Mutual Acceptance of Data, implying that data generated in the testing of chemicals in an OECD member country, or a partner country having adhered to the Decision, in accordance with OECD Test Guidelines and Principles of Good Laboratory Practice (GLP), be accepted in other OECD countries and partner counties having adhered to the Decision, for the purposes of assessment and other uses relating to the protection of human health and the environment.

 

Related Documents

 

Test Guidelines that have been deleted or replaced by updated versions

These obsolete Test Guidelines have been deleted in order to allow national/regional regulations that make reference to specific Test Guidelines and versions to be updated accordingly.  They should not be used for new testing. They are included here because it may be useful to consult them in the framework of the assessment of substances based on old study reports. The guaranties of Mutual Acceptance of Data (MAD) would not apply if these Test Guidelines were used for new testing.

In November 2012, the Joint Meeting of the Chemicals Committee and Working Party on Chemicals, Pesticides and Biotechnology decided on a transition period of 18 months, between the Council Decision and the effective deletion, for Test Guidelines that have been updated or deleted. For more information, please read the presentation: Update of Test Guidelines and the Mutual Acceptance of Data.

Further reading

 

Related Documents