Chemical safety and biosafety

OECD encourages the development of non-animal test methods for the detection of thyroid disrupters


The OECD Advisory Group on Endocrine Disrupters Testing and Assessment met on 16-17 October 2014 in Paris to discuss the development and update of Test Guidelines and related documents for the testing and assessment of endocrine disrupters.

One important endocrine system is the thyroid pathway. Thyroid hormones are of great importance for the development of Vertebrates. Certain OECD Test Guidelines on laboratory animals are already addressing toxicity to the thyroid hormone system, including, for example, the assessment of effects on brain development.

However, non-animal test methods are also currently needed for more efficient testing. Progress in developing non-animal tests for the thyroid pathway is thus a very high priority, in line with the “3-Rs” (Replacement, Reduction, Refinement) principles. A recent review published at OECD aimed at scoping potential tests. OECD countries are strongly encouraged to support the development of non-animal tests for the thyroid pathway that are applicable to the screening and assessment of endocrine disruption in humans and wildlife.

Proposals to develop standardised OECD Test Guidelines for the detection of thyroid disrupters should be made via the National Coordinators of the Test Guidelines Programme. 


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