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The OECD has released Version 3.3 of the QSAR Toolbox. It contains many new features and functionality improvements, including the DART (Developmental and Reproductive Toxicity) model, and the general mechanistic Cramer schemes. In addition, the QSAR Toolbox 3.3 contains updates of six databases (including ECHA CHEM), new QSAR models for explosive property and phototoxicity calculations, bug fixes and many other usability improvements.
In 2011, Brazil joined OECD’s Mutual Acceptance of Data (MAD) system ensuring that its chemical safety test data will be accepted by all 40 countries adhering to MAD. Originally limited to data developed in Brazil on pesticides, biocides and industrial chemicals, it now also includes veterinary products, feed additives, cosmetics, pharmaceutical products, sanitizers, wood preservative and treatments of effluents and natural ecosystems.
The OECD has published guidance to facilitate the ecological risk assessment of organometallic and organic metal salt substances. A strategy is presented based on key steps that first consider the fate of these substances in the environment, the identification of moieties of concern, and subsequently the selection of an appropriate path forward to either assess the inorganic moiety and/or the individual substance.
The OECD has just published two new Test Guidelines on human health hazard endpoint skin sensitisation. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS).
This toolbox is a compilation of resources relevant to chemical substitution and alternatives assessments. Alternative assessments are processes for identifying, comparing and selecting safer alternatives to replace hazardous chemicals with the objective of promoting sustainable production and consumption.
Micro-organisms play a fundamental role in the environment. Yet their role is the result of complex biogeochemical processes by consortia of micro-organisms and the function of individual species is not clear in many cases. This publication provides an overview of the current situation and relevant developments in environmental microbiology.
An addendum to the OECD Guiding Principles on Chemical Accident Prevention, Preparedness and Response to address Natural Hazards Triggering Technological Accidents (Natech) Risk Management has just been published. The addendum consists of a number of amendments to the Guiding Principles and the addition of a new Chapter to provide more detailed guidance on Natech prevention, preparedness and response.
OECD major events and activities relating to biotechnologies: latest developments are updated biannually in this Newsletter.
This guidance is intended to harmonise the way non-guideline in vitro test methods are described. This should in future facilitate an assessment of the relevance of test methods for biological activities and responses of interest, of the quality of data produced, irrespective of whether these tests are based on manual protocols or assay protocols adapted for use on automated platforms or high-throughput screening systems (HTS).
An IT system to develop and evaluate Adverse Outcome Pathways (AOP), the AOP Wiki, has been developed for testing by the Extended Advisory Group on Molecular Screening and Toxicogenomics and by AOP developers included in the work plan. The Wiki provides developers the necessary steps to capture scientific information in a user-friendly manner. The project is jointly led by the ECJRC and the USEPA.