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  • 3-April-2015

    English

    Emission Scenario Document (ESD) On The Use Of Adhesives

    This OECD Emission Scenario Document (ESD) is intended to provide information on the sources, use patterns, and potential release pathways of chemicals used in adhesive products, specifically during the use of adhesives in various industries.

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  • 3-April-2015

    English

    Safety Assessment of Foods and Feeds Derived from Transgenic Crops, Volume 1

    Volume I of this series compiles the science-based consensus documents of the OECD Task Force for the Safety of Novel Foods and Feeds from 2002 to 2008.

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  • 3-April-2015

    English

    Emission Scenario Document (ESD) On Industrial Use Of Industrial Cleaners

    This ESD covers the use of chemicals in the industrial cleaning process. The industry categories relevant to this ESD are industrial category (IC) 4 (electrical/electronic industry) and IC 8 (Metal extraction, refining and processing).The cleaners targeted in this ESD are for use on metallic parts used in machinery and in various metal industries.

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  • 3-April-2015

    English

    Safety Assessment of Foods and Feeds Derived from Transgenic Crops, Volume 1

    Volume I of this series compiles the science-based consensus documents of the OECD Task Force for the Safety of Novel Foods and Feeds from 2002 to 2008. They contain information for use during the regulatory assessment of food/feed products of modern biotechnology, i.e. developed from transgenic crops. Relevant information includes compositional considerations (nutrients, anti-nutrients, toxicants, allergens), use of the plant species as food/feed, key products and components suggested for analysis of new varieties for food use and for feed use, and other elements. These documents should be of value to applicants for commercial uses of novel foods and feeds, regulators and risk assessors in national authorities for their comparative approach, as well as the wider scientific community.
  • 11-March-2015

    English

    Policy Perspectives - Nanotechnology and Tyres: Greening Indsutry and Tyres

    An OECD policy perspective is now available which describes some of the major highlights from an OECD report on Nanotechnology and Tyres: Greening Industry and Transport.

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  • 16-February-2015

    English

    Expansion of Brazil's scope under OECD agreement on mutual acceptance of chemical safety data

    In 2011, Brazil joined OECD’s Mutual Acceptance of Data (MAD) system ensuring that its chemical safety test data will be accepted by all 40 countries adhering to MAD. Originally limited to data developed in Brazil on pesticides, biocides and industrial chemicals, it now also includes veterinary products, feed additives, cosmetics, pharmaceutical products, sanitizers, wood preservative and treatments of effluents and natural ecosystems.

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  • 16-February-2015

    English

    A new guidance is now available to facilitate the ecological risk assessment of organometallic and organic metal salt substances

    The OECD has published guidance to facilitate the ecological risk assessment of organometallic and organic metal salt substances. A strategy is presented based on key steps that first consider the fate of these substances in the environment, the identification of moieties of concern, and subsequently the selection of an appropriate path forward to either assess the inorganic moiety and/or the individual substance.

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  • 6-February-2015

    English

    Launch of 2 OECD Test Guidelines on human hazard endpoint skin sensitisation

    The OECD has just published two new Test Guidelines on human health hazard endpoint skin sensitisation. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS).

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  • 5-February-2015

    English

    Test No. 442C: In Chemico Skin Sensitisation - Direct Peptide Reactivity Assay (DPRA)

    The present Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS).This Test Guideline provides an in chemico procedure (Direct Peptide Reactivity Assay – DPRA) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.The DPRA is proposed to address the molecular initiating event leading to the skin sensitisation, namely protein reactivity, by quantifying the reactivity of test chemicals towards model synthetic peptides containing either lysine or cysteine. Cysteine and lysine percent peptide depletion values are then calculated and used in a prediction model to categorise a substance in one of four classes of reactivity for supporting the discrimination between skin sensitisers and non-sensitisers.
  • 5-February-2015

    English

    Test No. 442D: In Vitro Skin Sensitisation - ARE-Nrf2 Luciferase Test Method

    The present Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS).This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.The second key event on the adverse outcome pathway leading to skin sensitisation takes place in the keratinocytes and includes inflammatory responses as well as gene expression associated with specific cell signalling pathways such as the antioxidant/electrophile response element (ARE)-dependent pathways. The test method described in this Test Guideline (ARE-Nrf2 luciferase test method) is proposed to address this second key event. The cell line contains the luciferase gene under the transcriptional control of a constitutive promoter fused with an ARE element from a gene that is known to be up-regulated by contact sensitisers. The luciferase signal reflects the activation by sensitisers of endogenous Nrf2 dependent genes. This allows quantitative measurement (by luminescence detection) of luciferase gene induction, using well established light producing luciferase substrates, as an indicator of the activity of the Nrf2 transcription factor in cells following exposure to electrophilic test substances.Currently, the only in vitro ARE-Nrf2 luciferase test method covered by this Test Guideline is the KeratinoSensTM test method. Performance standards have been developed to enable the validation of similar test methods.
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